Acute Myocardial Infarction
Conditions
Brief summary
This research will explore the association between blood serum renalase and microcirculation obstruction in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). The investigators aim to identify potential risk factors for microcirculation obstruction in AMI patients after PPCI.
Interventions
None listed
Sponsors
The Third Xiangya Hospital of Central South University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years; 2. STEMI symptom onset time \< 12 hours; 3. STEMI symptom onset time 12-48 hours with persistent ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias; 4. High-risk NSTEMI; 5. Emergency PCI; 6. Voluntary informed consent.
Exclusion criteria
1. Non-obstructive acute myocardial infarction; 2. Severe chronic kidney disease (defined as estimated glomerular filtration rate \< 20 mL/min per 1.73 m²); 3. Life expectancy \< 1 year; 4. Pregnant or planning to become pregnant; 5. Emergency PCI failure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants with Microvascular Obstruction Assessed by Contrast-Enhanced Magnetic Resonance Imaging 3-7 Days After Percutaneous Coronary Intervention. | 3-7 days after PPCI | Microvascular obstruction (MVO) was qualitatively recognized as a subendocardial lack of enhancement at first-pass perfusion (FPP) sequences and as a hypointense region within the hyperintense infarcted area at early gadolinium enhancement (EGE) and late gadolinium enhancement (LGE) sequences. |
Countries
China
Contacts
Primary ContactWeihong Jiang
Backup ContactYe Chen
Outcome results
None listed