Correlation Between Preoperative Images of PPGL and Intraoperative Hemodynamics

Semiquantitative 131I-MIBG Scintigraphy Predicts Intraoperative Blood Pressure Fluctuation in Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06669481

Enrollment

159

Registered

2024-11-01

Start date

2020-01-01

Completion date

2023-04-30

Last updated

2024-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paraganglioma, Pheochromocytoma

Brief summary

This is a retrospective observational cohort study involving patients with suspected PPGLs who underwent 131I-MIBG scanning and surgical treatment between January 2020 and April 2023. The objective is to evaluate the correlation between MIBG imaging score and intraoperative hemodynamic fluctuations.

Detailed description

Interventions

OTHERSemiquantitative 131I-MIBG Scintigraphy Assessment

Patients received thyroid blockade using solution of potassium iodide before the examination. After intravenous administration of 111 MBq of 131I-MIBG, whole body planar images were acquired at 24 hours (Day 1) and 48 hours (Day 2), respectively.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients with suspected PPGLs who received 131I-MIBG scintigraphy and were treated by surgery

Exclusion criteria

* 1\) surgery was performed more than 6 months after 131I-MIBG scintigraphy; 2) tumor located in bladder where radioactive urine would influence assessment of tumor; 3) tumor was not resected as a whole; 4) resected tumor was not PPGLs confirmed by pathology; 5) 131I-MIBG scintigraphy images or intraoperative BP was not available for assessment.

Design outcomes

Primary

Measure	Time frame	Description
Difference of SBP ARV and MAP ARV in Different Groups	Intraoperative systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded automatically in a 5 min interval from the beginning to the end of surgery.	Mean arterial pressure (MAP) was calculated with the formula: MAP=1/3\SBP+2/3\DBP. ARV, which was defined as the average of absolute difference between successive BP values

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026