Allergic Rhinitis, Asthma
Conditions
Keywords
Mendelian Randomization, Genetic Association, Bidirectional Causality, Genome-Wide Association Study (GWAS), Respiratory Diseases
Brief summary
This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.
Detailed description
This observational study utilizes a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal association between allergic rhinitis and asthma. The genetic data for allergic rhinitis were obtained from the UK Biobank, encompassing 18,934 cases and 64,595 controls, while asthma data were derived from a Finnish biobank, including 20,629 cases and 135,449 controls. The Mendelian randomization analysis was performed using inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods to ensure robust causal inference. Additional tests, such as Cochrane's Q test and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), were applied to assess heterogeneity and pleiotropy, enhancing the reliability of the findings. The results are expected to provide insights into the bidirectional causal relationship between allergic rhinitis and asthma, potentially informing future prevention and treatment strategies.
Interventions
OTHERMendelian Randomization
This study utilizes a bidirectional Mendelian randomization approach to analyze genetic data from individuals with allergic rhinitis and asthma. No active intervention is applied; genetic variants serve as instrumental variables to assess causal associations between the conditions.
Sponsors
Zhibin Xu
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Inclusion criteria
* Individuals diagnosed with allergic rhinitis or asthma. * Availability of genetic data in the UK Biobank or Finnish biobank.
Exclusion criteria
* Individuals without genetic data. * Participants with incomplete phenotype or genotype data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Causal Effect of Allergic Rhinitis on Asthma Risk | Oct 24 2024 | Estimate the causal effect of allergic rhinitis on asthma risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods. |
| Causal Effect of Asthma on Allergic Rhinitis Risk | Oct 24 2024 | Estimate the causal effect of asthma on allergic rhinitis risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity Analysis Using MR-Egger Intercept Test | Oct 24 2024 | Perform sensitivity analysis using the Mendelian randomization-Egger (MR-Egger) intercept test to assess horizontal pleiotropy in the causal estimates between allergic rhinitis and asthma. |
| Sensitivity Analysis Using Leave-One-Out Test | Oct 24 2024 | Conduct a leave-one-out test to evaluate the robustness of the causal estimates between allergic rhinitis and asthma by sequentially removing each single nucleotide polymorphism (SNP). |
| Sensitivity Analysis Using MR-PRESSO | Oct 24 2024 | Use the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test to detect and correct for outliers, assessing heterogeneity in the causal estimates between allergic rhinitis and asthma. |
Countries
China
Outcome results
None listed