Propofol, Sevoflurane
Conditions
Brief summary
The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is: Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage? Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.
Interventions
DRUGAnesthesia Agent
intravenous anesthetic and inhalation anesthetic
Sponsors
Tongji Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.
Exclusion criteria
* have an endocrine system disease * pregnancy * have other brain disorders * take drugs that alter endocrine hormones * receive perioperative blood derivatives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of interleukin-10 | From enrollment to 3 months postoperation | Test the concentration of interleukin-10 of the participants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of interleukin-2 | From enrollment to 3 months postoperation | Test the concentration of interleukin-2 in participants |
| Concentration of interleukin-6 | From enrollment to 3 months postoperation | Test the concentration of interleukin-6 in participants |
| Concentration of interleukin-8 | From enrollment to 3 months postoperation | Test the concentration of interleukin-8 in participants |
| Concentration of tumor necrosis factor | From enrollment to 3 months postoperation | Test the concentration of tumor necrosis factor in participants |
| Concentration of interleukin-1 | From enrollment to 3 months postoperation | Test the Concentration of interleukin-1 in participants |
| length of stay | through study completion, an average of 6 months | The time from admission to discharge |
| costs | through study completion, an average of 6 months | Hospitalization expenses |
| Glasgow Coma Score | From enrollment to 3 months postoperation | The scores are ranging from 3 to 15. And higher scores mean a betterr outcome . |
| Concentration of S100B | From enrollment to 3 months postoperation | Test the concentration of S100B in participants |
Countries
China
Outcome results
None listed