Poor Responders
Conditions
Brief summary
New Approach For Ovarian PRP Injection for poor responders
Detailed description
Poor ovarian responders are at high risk of unsuccessful IVF/ICSI trials. In the last few years, many studies showed significant improvement of ovarian reserve parameters after PRP injection. There was no consensus regarding the route of injection, the volume injected, the location of PRP injection inside the ovary, the number of injection and the number of the cycle in which PRP is injected.
Interventions
None listed
Sponsors
Bassem Ayman Mahmoud Assaf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* AMH : \< 0.5 ng/ml * FSH: \> 10 miu but \< 25 miu. * AFC : \< 5 in both ovaries * Poor ovarian response, in a previous IVF/ICSI trial , resulting in 3 or fewer oocytes. * Normal uterine cavity , demonstrated by a recent hysteroscopy
Exclusion criteria
* Primary ovarian insufficiency with FSH \> 25 miu. * Previous ovarian surgery or Chemotherapy. * On going Anticoagulant use. * Carcinomas or a history of chronic pelvic pain. * Present infection. * Hemoglobin level lower than 11 g/L * platelet count lower than 150 x 10³/μL.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PRP effect on ovary for better fertility outcome | one year | This is a prospective cohort clinical observational study. Aiming at evaluating the clinical effects of injecting PRP(Platelet Rich Plasma) into ovaries, of poor responders, taking all measures which may improve the response rate. That is why we will inject PRP for 2 consecutive cycles, the first cycle via laparoscopy and the next cycle, via ultrasonography. |
Countries
Egypt
Outcome results
None listed