Using of Bone Marrow Stem Cell Concentrate with Platelet Rich Fibrin and Bone Graft in Bone Reconstruction of Upper Jaw Bony Cystic Defects, Comparing with Platelet Rich Fibrin with Bone Graft

Evaluation of Bone Marrow Stem Cells Concentrate with Platelet Rich Fibrin and Bone Graft in Bone Regeneration of Maxillary Cystic Defects Versus Platelet Rich Fibrin with Bone Graft (a Randomized Controlled Trial)

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06662604

Enrollment

Registered

2024-10-29

Start date

2024-10-26

Completion date

2026-02-22

Last updated

2024-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maxillary Cyst

Keywords

maxillary cyst, bone marrow stem cells, platelet rich fibrin PRF, bone graft, bone reconstruction, jaw cyst

Brief summary

Will the use of bone marrow stem cells with platelet rich fibrin enhance and accelerate the bone regeneration in the upper jaw cystic defects ?

Detailed description

Reconstruction of critical size bone defect in maxillofacial surgery is a great challenge, current practice of bone reconstruction still having problems like delay in bone regeneration (up to 12 months) and bone graft failure and low availability of autogenous bone graft. last decade stem cells therapy gained great interest, in many studies Bone marrow stem cells showed promising result in bone regeneration enhancing . Platelet Rich Fibrin PRF also capability of enhancing bone and tissue regeneration by releasing of certain protein molecules call growth factors that initiate sequential biological events resulting in stem cells migration into the site of bone defect and differentiation to bone formation cells (osteoblast cells ).

Interventions

BIOLOGICALBone marrow stem cells concentrate , platelet rich fibrin , bone graft

All participants will be treated with Bone marrow stem cells concentrate , platelet rich fibrin , bone graft.

BIOLOGICALplatelet rich fibrin and bone graft

All participants will treated with platelet rich fibrin PRF , bone graft.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Age range 18-50 years * Patients with a critical size maxillary cyst. (\>3 cm) * Patients that free of any significant medical conditions that could affect healing or outcomes.

Exclusion criteria

* Patients with large jaw cyst that endanger vital structures * Patients with significant medical condition * age under 18 years

Design outcomes

Primary

Measure	Time frame	Description
cyst volume	preoperative and 3, 6 months postoperative.	volumetric analysis of cystic defect 3, 6 months after treatment .

Contacts

Primary ContactMotea Abdulsalm Sanad, PHD

matea.sanad@dentistry.cu.edu.eg+20 1090696248

Backup ContactTareq El-Ghareeb, Professor

t.elghareeb@dentistry.cu.edu.eg+201282931864

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026