Topical Oral Anesthesia Adjuncts in Conventional Intubation on First-Pass Success Rate

Topical Oral Anesthesia Adjuncts in Conventional Intubation: A Randomized Controlled Trial Evaluating the Impact of Topical Oral Anesthesia on First-pass Success Rate

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06661967

Enrollment

110

Registered

2024-10-28

Start date

2024-10-25

Completion date

2026-04-30

Last updated

2024-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unrecognized Condition

Brief summary

This study aims to determine the first-pass success rate in video laryngoscopy and other parameters that topical anesthesia can affect during intubation.

Detailed description

In Thailand, conventional intubation or sedation without paralysis is still the most common method of intubation due to the lack of emergency physicians at primary care centers. A pilot study had shown that topical oral anesthesia can improve the first-pass success rate in conventional intubation by direct laryngoscopy. This study aims to determine the first-pass success rate in video laryngoscopy and other parameters that topical anesthesia can affect during intubation.

Interventions

DRUGLidocaine spray

Comparison of the success rate of endotracheal intubations between lidocaine spray and placebo

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Intervention model description

The participants are randomized into two groups. The first group receives lidocaine oral spray during preoxygenation while the latter will receive NSS spray as placebo.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients in emergency department that have indication for conventional intubation * Age \> 18 yr

Exclusion criteria

* Patient who undergo RSI * Patient who falls in cardiac arrest airway algorithm * Patient who is currently pregnancy * Known allergy to lidocaine

Design outcomes

Primary

Measure	Time frame	Description
First-pass success rate	1 Year	Comparison of the succession rate of endotracheal tube intubation

Countries

Thailand

Contacts

Primary ContactSila Thammongkol

Sila_th@outlook.com0853510161

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026