Age-related Functional Decline
Conditions
Keywords
aging, muscle health, body composition
Brief summary
This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.
Detailed description
This study is a randomized controlled trial of 6-month multidomain intervention program among community-living older adults with early physical impairments. Inclusion criteria are: (1) community-dwelling adults aged ≥ 65 years, (2) slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women); subjects with the following conditions will be excluded: (1) established diagnosis of dementia, Parkinsonism or other neurodegenerative disease (2) disable status: mobilitylimiting conditions, (3) active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on, (4) estimated life expectancy \<12 months, (5) current nursing home residents.
Interventions
BEHAVIORALMulti-domain intervention
Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults
Sponsors
National Health Research Institutes, Taiwan
National Yang Ming Chiao Tung University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aged ≥ 65 years * slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women)
Exclusion criteria
* established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions * active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on * estimated life expectancy \<12 months * current nursing home residents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Physical performance | baseline, 6 month | Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in IGF-1 | baseline, 6 month | Change in IGF-1 concentration from baseline to 6 months in all participants |
| Change in hs-CRP | baseline, 6 month | Change in hs-CRP concentration from baseline to 6 months in all participants |
| Change in Myostatin | baseline, 6 month | Change in Myostatin concentration from baseline to 6 months in all participants |
| Change in Activing A | baseline, 6 month | Change in Activing A concentration from baseline to 6 months in all participants |
| Change in DHEA-S | baseline, 6 month | Change in DHEA-S concentration from baseline to 6 months in all participants |
| Change in Relative appendicular skeletal muscle index (RASM) | baseline, 6 month | Change in RASM from baseline to 6 months in all participants |
| Change in body fat % | baseline, 6 month | Change in body fat % from baseline to 6 months in all participants |
| Change in Cognitive performance | baseline, 6 month | Change in Montreal Cognitive Assessment (MoCA), or Mini-mental state examination (MMSE) from baseline to 6months in all participants |
| Change from lipoproflie | baseline, 6 month | Change in Total Cholesterol, Triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol from baseline to 6months in all participants |
| Change in Follistatin | baseline, 6 month | Change in Follistatin concentration from baseline to 6 months in all participants |
Countries
Taiwan
Contacts
Primary ContactLi-Ning Peng, M.D., PhD
Outcome results
None listed