EGFR Exon 19 Deletion Mutation, Lung Cancer - Non Small Cell
Conditions
Keywords
Lung cancer, EGFR gene
Brief summary
EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.
Interventions
OTHERblood draw
A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
OTHERGene sequencing
Subjects will have their DNA sequenced within and around the EGFR gene.
Sponsors
Our Lady of the Lake Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-100 years old * Biologically born female * Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group) * No cancer diagnosis (Arm 2-health control)
Exclusion criteria
* less than 18 years of age * Biologically born male * Incarcerated at the time of participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in DNA sequence of EGFR gene | From enrollment to end of data analysis at 6 months | Subjects who have EGFR positive lung cancer will have their gene sequence compared to those that are EGFR negative and do not have lung cancer to look for differences in the sequence. |
Countries
United States
Contacts
Primary ContactCynthia Knox, MBA
Backup ContactChristine LeBoeuf, DNP
Outcome results
None listed