Polycystic Ovarian Syndrome (PCOS)
Conditions
Keywords
PCOS
Brief summary
The goal of this clinical trial is to determine the effects of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome. The main questions it aims to answer are: Does Coenzyme Q10 alter oxidative stress, inflammation and hyperandrogenism in women with Polycystic ovary syndrome. Participants will take Coenzyme Q10 200mg, once daily for a period of 3 months. The participants will be reassessed after 12 weeks by measuring Malondialdehyde MDA, C-reactive protein CRP, Sex hormone binding globulin SHBG.
Interventions
DIETARY_SUPPLEMENTCoenzyme Q10
Coenzyme Q10 will be given once daily, 200mg for the period of 3 months
Sponsors
College of Physicians and Surgeons Pakistan
University of Faisalabad
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Married Patients that presented with anovulatory infertility due to PCOS. * Unmarried Patients that presented with symptoms due to PCOS * All patients should fulfill Rotterdam criteria for PCOS
Exclusion criteria
* Male factor infertility ( oligospermia or aspermia) * Tubal factor infertility (abnormal hysterosalpingography) * Diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function * Autoimmune and Inflammatory disorders * Abnormal serum prolactin level * Smokers * Alcoholic beverage use * Use of anti diabetic, anti-obesity drugs, insulin or vitamin and mineral supplements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| effect of coenzyme q10 administration on polycystic ovary syndrome | from enrollment to the end of treatment at 12 weeks | Improvement in levels of oxidative stress , inflammatory and hyperandrogenism biomarkers in women with Polycystic ovary syndrome |
| The effect of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome | from enrollment to the end of treatment at 12 weeks | Oxidative stress in PCOS is leads to imbalance in antioxidant and oxidant levels in the body, along with production of reactive oxygen species. Insulin resistance has a key role in the PCOS pathogenesis by promoting oxidative stress and promoting acute and chronic Inflammation. Studies have shown that inflammatory markers are raised in PCOS along with decreased levels of anti-inflammatory biomarkers. Coenzyme Q10 is a natural vitamin, acts as an antioxidant, have shown an constructive impact on inflammatory and endothelial dysfunction biomarkers and also effects androgen levels. Effect of Coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism will be accessed by biomarkers Malondialdehyde MDA, C-reactive protein CRP and Sex hormone binding globulin SHBG. Ideally levels of MDA, CRP would decrease and SHBG levels would increase after Coenzyme Q10 supplementation. This study would measure these three biomarkers before and after the intervention. |
Countries
Pakistan
Contacts
Primary Contacthira zahid, MBBS, M.Phil.
Backup ContactSana Akram, MBBS, FCPS
Outcome results
None listed