Iron Deficiency (Without Anemia)
Conditions
Keywords
oral iron supplementation, serum ferritin
Brief summary
Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin, as well as its protein characteristics, following the administration of a single iron dose
Interventions
DIETARY_SUPPLEMENT40mg oral iron dosing
Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate
DIETARY_SUPPLEMENT100mg oral iron dosing
Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate
DIETARY_SUPPLEMENT180mg oral iron dosing
Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate
Sponsors
Jessica Rigutto
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Low iron stores (SF levels \< 30 µg/L), * no anemia (Hb \> 120 g/L) * no inflammation (CRP \< 5 mg/L) * 18 to 45 years old. * Body weight \<70 kg * Normal body Mass Index (18.5-26.5 kg/m2)
Exclusion criteria
* Any chronic or acute disease * Consumption of mineral and vitamin supplements since screening and over the study period * Blood transfusion, blood donation or significant blood loss over the past 6 months, * Pregnant or breastfeeding, * Continuous/long-term use of medication during the whole studies (except for contraceptives) * Therapeutic iron infusion over the past 6 months, * Known hypersensitivity or allergy to iron supplements, * Intention to become pregnant over the course of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum ferritin | study day 1 | Serum ferritin concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum iron | study day 0 | serum iron concentration in circulation |
| Isotopic composition of Serum Ferritin | study day 0 | shift in stable iron isotopes in serum ferritin |
| Structural characteristics of Serum Ferritin | study day 0 | Proteomics |
| Fractional iron absorption | study day 14 | Erythrocyte iron incorporation of stable iron isotope |
| Hemoglobin | study day 0 | Hemoglobin concentration |
| Serum ferritin | study day 0 | Serum ferritin concentration |
| alpha(1)-acid-glycoprotein | study day 0 | alpha(1)-acid-glycoprotein concentration in serum |
| soluble transferrin receptor | study day 0 | soluble transferrin receptor in serum |
| C-reactive protein | study day 0 | C-reactive protein concentration in serum |
Countries
Switzerland
Outcome results
None listed