Skin Pigment, Skin Red
Conditions
Brief summary
This project aims to conduct safety and efficacy tests on the skin for the ingestion of Astrion Vitality Capsules, containing A. membranaceus and C. Asiatica roots, and the topical application of Astrion Vitality Cream. The goal is to develop health and skincare products that regulate physiological functions, promote overall wellness, and enhance skin beauty.
Interventions
DIETARY_SUPPLEMENTACS Topical Treatment Group
The topical group applied the ACS cream to the face twice daily (morning and night) for 4 weeks.
DIETARY_SUPPLEMENTTopical Placebo Group
The topical group applied the cream (without ACS) to the face twice daily (morning and night) for 4 weeks.
DIETARY_SUPPLEMENTOral Treatment + Topical Treatment Group
The combination group used both the topical and oral ACS products for 12 weeks.
DIETARY_SUPPLEMENTACS Oral Treatment Group
The oral group ingested one ACS capsule twice daily after breakfast and dinner for 12 weeks.
DIETARY_SUPPLEMENTOral Placebo Group
The oral group ingested one capsule (without ACS) twice daily after breakfast and dinner for 12 weeks.
DIETARY_SUPPLEMENTOral Treatment + Topical Placebo Group
The combination group used both the topical and oral products without ACS for 12 weeks.
Sponsors
Chia Nan University of Pharmacy ＆ Science
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Subjects aged ≥18 years.
Exclusion criteria
* Non-voluntary participants. * Subjects diagnosed with skin diseases, cirrhosis, or chronic renal failure by a -physician. * Individuals with known allergies to cosmetics, drugs, or food. * Pregnant or breastfeeding women. * Individuals taking medication for chronic diseases. * Subjects who, within 12 weeks prior to the test, have undergone laser facial treatments, chemical peels, or experienced prolonged sun exposure (more than 3 hours of direct sunlight in a week). * Students taught by the investigator. * Individuals unwilling to allow the publication of photos of the experimental results.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| skin melanin | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | Skin elastometer (Soft Plus) was utilized to measure skin melanin. Units: arbitrary units |
| Skin brightness | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | Skin color difference analyzer (Chroma Meter MM500) was utilized to measure skin brightness |
| skin moisture | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | Skin moisture meter (Corneometer CM825) was utilized to measure skin moisture. Units: arbitrary units |
| skin elasticity | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | Skin elastometer (Soft Plus) was utilized to measure skin elasticity. Units: arbitrary units |
| collagen density content | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | Subcutaneous collagen scanner (DermaLab® Series SkinLab Combo) was utilized to measure skin collagen. Units: arbitrary units |
| skin surface topography | The topical group applied ACS cream to the face twice daily for 4 weeks. The oral group took one ACS capsule twice daily after meals for 12 weeks. The combination group followed both regimens for 12 weeks. A placebo group, identical in appearance but wit | VISIA Micro-Analysis Skin Image Analyzer was utilized to measure skin texture. Units: arbitrary units |
Countries
Taiwan
Outcome results
None listed