Postprandial Hypotension, Hypoglycemia
Conditions
Keywords
Hypotension, hypoglycemia, insulin, mixed meal, adults, postprandial
Brief summary
The goal of this observational study is to learn about the relationship between postprandial hypotension and insulin levels in adults. The main question it aims to answer is: Is the incidence of postprandial hypotension high in patients who undergo mixed meal test? Is insulin level higher in individuals with postprandial hypotension compared to those without during a mixed meal test? Patients with postprandial symptoms were scheduled for a mixed meal test, during which plasma glucose, insulin, C-peptide, blood pressure, and heart rate were measured at specific time points.
Interventions
OTHERMixed meal test
The biochemical parameters, blood pressure, and heart rates of participants undergoing the mixed meal test will be recorded over a 5-hour period.
Sponsors
Ankara Yildirim Beyazıt University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults with postprandial symptoms
Exclusion criteria
* Individuals with prediabetes or diabetes, * Those aged 65 and above, * Patients using antihypertensive medications or with known hypertension, * Those with active infections, * Congestive heart failure, * Peripheral artery disease, * Advanced-stage dementia, * Individuals who could not provide a history or were unable to cooperate, * Patients using medications that could induce hypoglycemia (oral antidiabetics, insulin, beta-blockers, hydroxychloroquine, bromocriptine, etc.) * Those with conditions that could cause hypoglycemia (uncontrolled hypothyroidism, adrenal insufficiency, growth hormone deficiency, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic blood pressure | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | mmHg |
| Blood glucose | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | mg/dL |
| Blood insulin | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | uIU/mL |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood C-peptide | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | ng/mL |
| Diastolic blood pressure | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | mmHg |
| Heart rate | During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min) | bpm |
Countries
Turkey (Türkiye)
Outcome results
None listed