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R01.Aim 2.Study 1: IsoReach

Error-enhanced Learning & Recovery in 2 & 3 Dimensions

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06656754
Enrollment
56
Registered
2024-10-24
Start date
2024-11-17
Completion date
2029-05-01
Last updated
2025-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Brief summary

To determine the effects of 3D isometric movement training in healthy participants and impaired participants due to a stroke.

Detailed description

Researchers have found that neurotypical adults are able to train movement skills when sensory sources, such as proprioception, are altered using isometric conditions and visual feedback in a two-dimensional environment.Building off this knowledge, the investigators plan to apply similar techniques to both neurotypical adults and stroke survivors with impaired movement, but in a three-dimensional environment. The investigators will ask participants to practice a unilateral virtual reality targeted reaching task using a robotic arm in a 3D visual display system mounted over the arm. Participants will be given visual feedback of their arm through a virtual avatar displayed on the screen. First, they will complete unconstrained targeted reaching and then complete targeted reaching with the robotic arm constrained in a fixed position (isometric movement). The forces applied to constrain the robotic arm will be translated to the virtual avatar arm on the screen, and it will look as if their arm is moving. The investigators will compare perpendicular errors (maximum difference between the ideal reaching trajectory and the actual) made in unconstrained and constrained movement conditions. The investigators aim to determine if the two movement conditions yield similar error responses when sensory sources are altered in a 3D environment.

Interventions

OTHERIsometric Reaching

The intervention of Isometric Reaching is the process of restricting the participant's hand movement in place, while using the forces they apply to the robot handle to drive a reaching arm simulation

Sponsors

Shirley Ryan AbilityLab
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

, neurotypical participants * 18 years old No history of stroke Ability to provide informed consent .

Exclusion criteria

, neurotypical participants Severe medical problems (including cardiovascular, orthopedic, or neurological) Medical problems affecting movement, range of motion, strength, or coordination of the upper extremities. Visual deficits that would influence the ability to perform the experiment . This will be assessed using the following assessments: 1. Visual field deficits will be assessed using the BIVABA acuity testing. (cutoff score > 20/100) 2. Depth perception deficits will be assessed using the Stereofly test (require at least an angle of stereopsis at 16 inches is 3,552 seconds of arc). 4\) Blood pressure above 140 systolic and/or 90 diastolic mmHG 5\) Blood oxygen reading of less than 92% by finger pulse oximeter testing. Inclusion Criteria , Stroke participants * 18 years old Chronic stroke (8+ months post) Available medical records and radiographic information about lesion locations Hemiparesis Primary motor cortex involvement Some degree of both shoulder and elbow movement capability

Design outcomes

Primary

MeasureTime frameDescription
Perpendicular Errorthrough study completion, an average of 1 year.Maximum distance between the ideal reaching trajectory and the actual trajectory made in unconstrained and constrained movement conditions

Countries

United States

Contacts

Primary ContactArturo Ramirez
aramire4@uic.edu312-238-1379
Backup ContactCourtney Celian, OTR/L

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026