Cardiac Surgery, Neurologic Manifestations, Postoperative Cognitive Dysfunction
Conditions
Keywords
Dexmedetomidine, Cardiac Anesthesia, Neuron Specific Enolase, Randomized Controlled Trial
Brief summary
To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery
Detailed description
This randomized controlled study was conducted to evaluate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing elective open-heart surgery. Patients were randomly assigned into two groups: a dexmedetomidine group receiving intravenous dexmedetomidine infusion during surgery and a control group receiving normal saline infusion as placebo in addition to standard anesthesia. Postoperative cognitive function was assessed using the Mini-Mental State Examination (MMSE). Serum neuron-specific enolase (NSE) levels were measured as a biomarker of neuronal injury. Intraoperative depth of anesthesia was monitored using the bispectral index (BIS). The aim of the study was to investigate whether dexmedetomidine administration could reduce postoperative cognitive dysfunction and neuronal injury in patients undergoing cardiac surgery.
Interventions
DRUGDexmedetomidine
Dexmedetomidine infusion during open heart surgery
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Participants, investigators, and outcome assessors were blinded to group allocation. Dexmedetomidine and placebo solutions were prepared in identical syringes by an independent anesthesiologist not involved in patient management or data collection.
Intervention model description
Patients undergoing elective open-heart surgery were randomly assigned in a 1:1 ratio to receive either dexmedetomidine infusion or placebo (normal saline) during surgery.
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients of both sexes undergoing elective open-heart surgery
Exclusion criteria
* Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval. Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum neuron-specific enolase levels | Preoperative baseline and 12 hours after surgery | Serum neuron-specific enolase levels will be measured as a biomarker of neuronal injury. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative cognitive function | Preoperative baseline, and at 1 day, 3 days, and 7 days after surgery | Cognitive function will be evaluated using the Mini-Mental State Examination (MMSE). |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORSalaheldin A Abdelaziz, MSc
Sohag University
Outcome results
None listed