Healthy
Conditions
Keywords
Beta2-adrenergic stimulation, Skeletal muscle hypertrophy
Brief summary
The purpose of the project is to investigate the muscle anabolic response to acute beta2-adrenergic stimulation in young healthy men and women.
Interventions
DRUGSalmeterol
Participants are administered 200 µg salmeterol (8 puffs) from a MDI device
DRUGPlacebo
Participants are administered placebo (8 puffs) from a MDI device
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Inclusion Criteria: * Age 18-40 * Physically active \>5 hours a week * Maximum oxygen uptake classified as high or very high
Exclusion criteria
* Active smoker currently or within the past 5 years * Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women) * Chronic or acute illness deemed by the responsible study physician to affect the test parameters * Deviation from the study protocol * Lean mass index \>21 kg/m² * Pregnancy * Smoker * Blood donation during the past 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Power output during sprint testing | Through study completion, an average on 2 weeks | Power output measured in Watts during a sprint on a bike ergometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Power output during time trial | Through study completion, an average on 2 weeks | Mean power output measured in Watts during a time trial on a bike ergometer |
Other
| Measure | Time frame | Description |
|---|---|---|
| Quadriceps strength | Through study completion, an average on 2 weeks | Maksimal torque (Nm) achieved during isometric contraction |
Countries
Denmark
Outcome results
None listed