Contact Lens Complication
Conditions
Keywords
Corneal Neuromediator, Soft contact lenses, Corneal optical density, Corneal aberration
Brief summary
To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction
Detailed description
This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: \> 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence
Interventions
This study does not involve any interventions
Sponsors
yuhao shao
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* age ≥ 18 years with stable refraction for at least two years; * spherical equivalent (SE) \< -6.00 D; * corrected distance visual acuity of 20/20 or better; * no history of using rigid gas permeable lenses or orthokeratology (OK) lenses prior to examination
Exclusion criteria
\- a history of moderate to severe dry eye as well as any ocular or systemic disease that would contraindicate laser refractive surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal stromal lenticule Neuromediators | baseline | Corneal neuromediators, including NGF(pg/mL), CGRP(pg/mL), SP(pg/mL), IGFBP-1(ng/mL), and MANF(pg/mL), which play pivotal roles in maintaining normal physiological functions of the cornea. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Corneal Aberration | baseline | Preoperative corneal aberration measurements were performed using a Scheimpflug tomography system (Pentacam; Oculus GmbH, Wetzlar, Germany). Images of the highest quality (designated as OK) were selected for analysis. The coefficients for a standardized diameter of 8 ?mm were examined, followed by an assessment of the clinical significance of total higher-order aberrations (HOA, mm), spherical aberration (Z4, 0, mm), horizontal coma (Z3, 1, mm), vertical coma (Z3, -1, mm), horizontal trefoil (Z3, 3, mm), and oblique trefoil (Z3, -3, mm) in relation to visual quality. |
| Corneal Densitometry | baseline | The Pentacam HR was used to collect data on corneal densitometry values, which were expressed in grayscale units (GSUs), playing a crucial role in quantifying corneal clarity by monitoring transient haze-like reactions. The cornea was divided into four annular zones (0-2 mm, 2-6 mm, 6-10 mm, and 10-12 mm), each exhibiting distinct corneal densitometry values. Based on the anatomical layers of the cornea at different depths, it consists of four layers: a superficial anterior layer of 120 μm, a posterior layer located within the innermost part of the cornea measuring 60 μm; central layers calculated by subtracting thickness of the anterior and posterior layers from the total layer thickness; and a total layer. Corneal densitometry values were measured in the 0-2 mm and 2-6 mm to correspond to the corneal optical zone diameter of SMILE. |
Countries
China
Contacts
Primary Contactmin Li, Dr
Backup ContactYuhao Shao, MD
Outcome results
None listed