Cataract
Conditions
Keywords
cataract; femtosecond laser; cytokines; oxidative stress; miosis;
Brief summary
Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency system and delivers energy pulses in nanojoule levels, while Lensx platform (Lensx, Alcon Laboratories, Inc.) used a high-energy laser system. In femtosecond laser-assisted cataract surgery, the laser pretreatment is associated with breakdown of blood-aqueous barrier (BAB) associated with increased aqueous total prostaglandin, cytokines and Oxygen-free radicals concentration. The prostaglandin rise immediately after laser pretreatment is further thought to be the causative factor for the intraoperative miosis in femtosecond laser-assisted cataract surgery. However, the analysis of anterior chamber inflammatory factors, oxidative stress, and pupil size after femtosecond laser-assisted cataract surgery between different laser platforms has not been investigated in clinical studies. Understanding the cytokine and chemokine changes related to the laser pretreatment provides better insight into the inflammatory response in femtosecond laser-assisted cataract surgery.
Interventions
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Age related cataracts over 50 years old, nuclear grades II-III
Exclusion criteria
* Eye diseases: glaucoma, uveitis * Systemic diseases: autoimmune diseases such as diabetes and rheumatism ③ Intraoperative complications: ④ Medication history: Over 1 month before surgery, systemic or local hormones, NASIDs ⑤ History of eye surgery (including YAG laser and fundus laser), trauma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PGE2 | through study completion, an average of half a year | The concentrations of PGE2 in aqueous humor |
| cytokines (IL-1β、IL-6, IL-8、TNF-a) | through study completion, an average of half a year | The concentrations of cytokines (IL-1β、IL-6, IL-8、TNF-a) in aqueous humor |
| MDA | through study completion, an average of half a year | The concentrations of MDA in aqueous humor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| central corneal thickness | through study completion, an average of half a year | The central corneal thickness was measured |
| central macular thickness | through study completion, an average of half a year | The central macular thickness was measured |
Countries
China
Outcome results
None listed