Heart Failure
Conditions
Keywords
sST2 biomarker, Minnesota Questionare, HIITS
Brief summary
This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient
Detailed description
The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I &II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.
Interventions
OTHERHIITS
Frequency: HIIT will be in 2 supervised sessions per week for 12 weeks on the treadmill. session duration from 30-40 min including the waming up and cooling down Intensity: HIIT included 4 minute intervals aiming 60-85% of heart rate reserve
OTHERMICT
Frequency: Moderate continuous training is scheduled 2 times per week for 12 weeks. Intensity: exercise had been applied on the treadmill with 40%-59% of heart rate reserve) session duration from 30-40 min including the warming up and cooling down
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
1. Patients will receive high intensity interval training (HIIT) 2. Patients will receive moderate intensity continuous training (MICT)
Eligibility
Sex/Gender
MALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* The patients selection was according to the following criteria: * Patients diagnosed with chronic heart failure (New York heart association class I& II) with systolic left ventricular dysfunction. * Their left ventricular ejection fraction (LVEF) \<40%. * Medical treatment was optimized at least three months prior to study entry. * All patients didn't participate in any rehabilitation programs prior to the study.
Exclusion criteria
* Patients who had met one of the following criteria were excluded from the study: 1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study. 2. Pacemakers. 3. Chronic obstructive pulmonary disease. 4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures) 5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| soluble ST2 biomarker level | before the start of the trail and at the end of the trail 3 months | sample was taken at the cubited vein at the beginning of the program and also at its end |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ejection fraction | before the start of the trail and at the end of the trail 3 months | Left ventricular systolic dysfunction was assessed using the ejection fraction by 2D simpson method |
| mannisota of daily living questionnaire score | before the start of the trail and at the end of the trail 3 months | The twenty one item questionnaire was usedfrom 0 (none) to 5 (very much). It provides a total score (range 0-105, from best to worst HRQoL), as well as scores for two dimensions, physical (8 items, range 0-40) and emotional (5 items, range 0-25). The other eight items (of the total of 21) are only considered for the calculation of the total score. |
| peak exercise response | before the start of the trail and at the end of the trail 3 months | monitoring the peak exercise response |
Countries
Egypt
Outcome results
None listed