Evaluation of Perfusion and Oxygenation in Muscle of Patients With PAD Undergoing LER

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06645353

Enrollment

Registered

2024-10-16

Start date

2024-11-30

Completion date

2025-07-31

Last updated

2024-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Arterial Disease

Brief summary

During this IIT, the MSOT (Multispectral Optoacoustic Tomography ) Acuity Echo will be used to scan participants with Peripheral Arterial Disease assess MSOT Multispectral Optoacoustic Tomography (single-wavelength and hemoglobin-related parameters) in the Tibialis Anterior, and flexor hallucis brevis, at multiple time-points before, during and after interventional Lower Extremity Revascularization (LER ). Primary aim of the study ist the Comparison of the difference between oxygenated, deoxygenated hemoglobin and oxygenation in the tibialis anterior, and flexor hallucis brevis, at multiple time-points before, during and after interventional Lower Extremity Revascularization.

Interventions

DEVICEMSOT Multispectral Optoacoustic Tomography

MSOT Multispectral Optoacoustic Tomography, single-wavelength, HbT, Hb, HbO2, collagen and mSO2 (700-1.100 nm wavelength range, in 10 nm increments) in the tibialis anterior and flexor hallucis brevis, at multiple time-points before, during and after interventional LER Lower Extremity Revascularization .

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* • Written consent of the participant after being informed * Adults above 18 years * Participants with PAD stage 4 - 6 (Rutherford) with indication for interventional LER

Exclusion criteria

* • Participants with previous LER on the same leg * Participants less than 18years * Pregnancy * Participants with tattoos in the scan area * Participants with no clinical indication for interventional LER * Missing consent form

Design outcomes

Primary

Measure	Time frame	Description
MSOT Multispectral Optoacoustic Tomography,	baseline pre LER, 30 minutes post LER, 24 hours post LER, 48hours post LER	single-wavelength, HbT, Hb, HbO2, collagen and mSO2 (700-1.100 nm wavelength range, in 10 nm increments) in the tibialis anterior and flexor hallucis brevis, at multiple time-points before, during and after interventional LER Lower Extremity Revascularization .

Contacts

Primary ContactAstrid Friedel

astrid.friedel@medunigraz.at031638578017

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026