Obesity Doppler in Term Pregnancy

The Effect of Maternal Obesity on Umbilical and Uterine Artery Doppler in Term Pregnancy : a Cross-sectional Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06644911

Enrollment

240

Registered

2024-10-16

Start date

2025-01-20

Completion date

2026-01-31

Last updated

2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Doppler Measurement of Uterine Artery

Brief summary

Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight. Umbilical and uterine artery Doppler is widely accepted as a useful tool for monitoring high-risk pregnancies. Normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. Obesity has little impact on uterine vascular changes reflected by the early uterine artery PI. However, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. Many studies have examined the relationship between BMI and Doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

1. Singleton pregnancy 2. Gestational age ≥ 37 weeks 3. Absence of fetal structural abnormalities 4. Absence of maternal comorbidities and/or complications. 5. Obese women (BMI ≥ 30 kg/m2) \[11\]. 6. Normal weight (BMI 18.5-24.9) \[11\].

Exclusion criteria

1. Placenta previa 2. Women with antepartum hemorrhage. 3. Smokers and alcohol consumers 4. Preeclampsia 5. Diabetes mellitus 6. Women need urgent termination of pregnancy.

Design outcomes

Primary

Measure	Time frame	Description
The difference between uterine and umbilical artery Doppler resistant index	at 37 weeks of pregnancy	The difference between uterine and umbilical artery Doppler indices between normal weight and obese pregnant women ≥ 37 weeks.

Countries

Egypt

Contacts

Primary ContactMohammed Khairy Ali, MD

mohammedelkosy@aun.edu.eg01005537951

Outcome results