Distribution of CYP2D6 Multiplication, CYP2D6*5, and Clinical Implications in Postoperative Patients Receiving Tramadol Analgesia in the Minangkabau Ethnic Group, Indonesia

Conditions

Post Operative Analgesia, Tramadol

Keywords

Tramadol, Post Operative, Minangkabau

Brief summary

Cytochrome P450 2D6 (CYP2D6) is an important enzyme in metabolizing commonly used drugs such as Tramadol hydrochloride (widely used opioid analgesic). Genetic polymorphisms of the CYP2D6 gene have been shown to influence the pharmacodynamic properties of the administered drug. This study aimed to screen 63 postoperative patients (wild-type, CYP2D6\*5, and CYP2D6 multiplication) of Minangkabau ethnicity in West Sumatera, Indonesia, who received tramadol using a modified long PCR method and to investigate the clinical impact of tramadol on the patients.

Detailed description

VAS of 63 patients was determined by injecting tramadol at a dose of 100 mg 30 minutes before the operation was completed. It was observed in the recovery room at 30, 60, and 120 minutes. Tramadol had an onset time of 15-60 minutes, with peak effectiveness at 2-6 hours postoperatively. Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain).

Rinal Effendi, Aufa Rizqia Haz, Asrul Muhamad Fuad, Bagus Dermawan, Nuruliawaty Utami et al. (6 authors)

F1000Research2025-08-22

10.12688/f1000research.155988.2

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia.

Effendi R, Rizqia Haz A, Muhammad Fuad A, Dermawan B, Utami N, Desriani.

2024-01-01

10.12688/f1000research.155988.3

Interventions

DRUGPost Operative Analgesia

administering 100 mg of intravenous tramadol 30 minutes before the operation is completed

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SCREENING

Masking

NONE

Intervention model description

VAS of 63 patients was determined by injecting tramadol at a dose of 100 mg 30 minutes before the operation was completed. It was observed in the recovery room at 30, 60, and 120 minutes. Tramadol had an onset time of 15-60 minutes, with peak effectiveness at 2-6 hours postoperatively. Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain).

Eligibility

Sex/Gender

ALL

Age

No minimum to 65 Years

Healthy volunteers

No

Inclusion criteria

* Post operative patients who get analgesic tramadol

Exclusion criteria

* No

Design outcomes

Primary

Measure	Time frame	Description
Determination of Patients' Visual Analogue Scale (VAS)	. It was observed in the recovery room at 30, 60, and 120 minutes	Pain level was categorized into 0 (no pain), 1-3 (signifying mild), 4-6 (middle), and 7-10 ( heavy pain).

Countries

Indonesia

Outcome results

None listed