Carbon Monoxide Intoxication
Conditions
Keywords
Intoxication, Carbon monoxyde, Carboxyhemoglobin, COHb, Carboxyhemoglobin capillary
Brief summary
The main goal of COCAP is to compare COHb (carboxyhemoglobin) levels measured from venous or arterial samples with those measured from capillary samples in patients suspected of Carbon Monoxide intoxication.Patient participation in the study will be limited to capillary sampling (approx. 5-15 minutes).
Interventions
DIAGNOSTIC_TESTBlood drop sampling
The process: blood drop sampling Technique: capillary sampling Frequency: Once Time: 5 minutes Sample collection volume: 1mL Total collection volume: 1 mL
Sponsors
University Hospital, Angers
Nantes University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patient admitted to emergency department * Presenting one or more clinical signs (asthenia, headache, nausea, vomiting, loss of consciousness, etc.) and a history compatible with CO intoxication (collective symptoms, notion of smoke, activation of a detector, etc.).
Exclusion criteria
* Minors * Patients under protective supervision (safeguard of justice, curatorship, guardianship) * Incarcerated patients * Pregnant or breast-feeding women * Patients refusing to take part in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the accuracy of capillary HbCO measurement (compared with venous or arterial HbCO) in patients with suspected CO poisoning. | 15 minutes | The main goal will be determined by the mean bias and limits of agreement between capillary and venous (or arterial) sampling (Bland-Altman analysis). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Determine the diagnostic performance of capillary measurement | 15 minutes | Determine the sensitivity, specificity, ROC curve, area under the ROC curve, positive and negative predictive values and likelihood ratios (positive and negative) of capillary measurement for the diagnosis of CO intoxication. The linear correlation coefficient between venous (or arterial) HbCO and capillary HbCO will also be calculated. |
| Assess the technical difficulties of different blood sampling processes (Measurement of the number of attempts and failure rate for samples) | 15 minutes | — |
| Assess the technical difficulties of different blood sampling processes (Measurement of the time required to take each sample) | 15 minutes | — |
| Analyse the technical difficulties associated with the analysis of the two samples (Time between sampling and HbCO result) | 15 minutes | — |
| Analyse the technical difficulties associated with the analysis of the two samples (percentage of samples that cannot be analysed by the laboratory) | 15 minutes | — |
Countries
France
Contacts
Primary ContactJules Galy
Backup ContactFrançois JAVAUDIN, MD-Phd
Outcome results
None listed