Effect of Maternal Supplementation From Preconception to Lactation on Child Growth and Development

Effect of Maternal Multiple Micronutrient Supplementation From Preconception Through Lactation on Child Growth and Development in Rural Pakistan: A Follow-up Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06641349

Enrollment

150

Registered

2024-10-15

Start date

2025-01-13

Completion date

2025-06-04

Last updated

2025-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Growth &Amp; Development, Malnutrition

Keywords

malnutrition, multiple micronutrient supplement, neurodevelopment, growth

Brief summary

The goal of this observational study is to learn about the long-term effects of maternal multiple micronutrient supplementation from preconception through to lactation on child neurodevelopment and growth in a resource-limited setting where there is a high burden of malnutrition. The main questions it aims to answer are: * Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child neurodevelopment? * Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child growth? This is a cross-sectional follow up study to a substudy of breastmilk composition and infant growth within the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial, wherein mothers were randomized to receive a multiple micronutrient supplement from preconception through to lactation or the standard of care (ClinicalTrials.gov Identifier: NCT04451395).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

4 Years to No maximum

Healthy volunteers

Inclusion criteria

* Child participated in the MaPPS Trial Breastmilk Sub-study at 3-months of age * Child has reached their fourth birthday * Child is available in the study catchment area (Matiari District)

Design outcomes

Primary

Measure	Time frame	Description
Full scale IQ score	At 4 years of age	Wechsler Preschool and Primary Scale of Intelligence (WPPSI), minimum score: 40 and maximum score: 160 (higher scores mean a better outcome)

Secondary

Measure	Time frame	Description
Fine and gross motor skills score	At 4 years of age	Bruininks-Oseretsky Test of Motor Proficiency, 2nd edition (BOT-2) Brief Form, minimum score: 0 and maximum score: 80 (higher scores mean a better outcome)
Height	At 4 years of age	—
Head circumference	At 4 years of age	—

Other

Measure	Time frame
Weight	At 4 years of age
Middle upper arm circumference	At 4 years of age

Countries

Pakistan

Outcome results