Bradykinesia, Parkinson's Disease (PD), Upper Limb Function
Conditions
Brief summary
A randomized, double-blind, sham-controlled unicenter clinical trial was used to investigate the effectiveness and neural mechanism of high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb bradykinesia in patients with Parkinson's disease.
Interventions
DEVICEhigh frequency-repetitive transcranial magnetic stimulation
rTMS involves the repeated application of magnetic pulses to specific areas of the brain. These pulses are delivered using a coil placed on the scalp, which generates a magnetic field that induces electrical currents in the brain tissue.
DEVICEsham stimulation
The sham group receives 10 sessions of rTMS stimulation with a sham stimulation coil, which emits the same sound and vibration as the active coil but does not produce any induced electrical currents.
Sponsors
Shanghai Jiao Tong University School of Medicine
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Hoehn and Yahr (HY) stage 1-2 * Able to understand and cooperate with the study * Predominantly characterized by bradykinesia * Onset on the left side
Exclusion criteria
* Contraindications for TMS including DBS surgery, Ventriculoperitoneal shunt, etc * Other neurological disorders * Significant resting tremor, with MDS-UPDRS-III tremor score ≥3 * Resting threshold cannot be measured * Received other TMS treatments within the last 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (MDS-UPDRS) | 2 weeks and 4 weeks | Change in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) total score of part III from Day 1 to 1 year. The part III of the MDS-UPDRS assess motor function in best on phase. The score range is 0-132, where a higher score means more severe motor impairment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cortical activation detected by fNIRS | 2 weeks and 4 weeks | Using near-infrared brain imaging systems, have patients perform finger tapping, fist clenching, and forearm rotation movements to observe brain region activation. |
Countries
China
Outcome results
None listed