Alzheimer Disease, Brain Health, Cardiovascular Diseases, Dementia, Gestational Hypertension, Pre-Eclampsia, Pregnancy Related
Conditions
Brief summary
The purpose of this study is to learn if hypertensive disorders during pregnancy affects brain health in midlife.
Interventions
DIAGNOSTIC_TESTA combination of various tests and biomarkers will be completed to understand the effect of hypertensive disorders of pregnancy on brain health in midlife.
Participants will be asked to complete a blood draw, 5-lead ECG, MRI, a series of cognitive assessments, dietary assessments, monitor sleep and physical activity and DXA scan.
Sponsors
University of Kansas Medical Center
National Institute on Aging (NIA)
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 54 Years
Healthy volunteers
Yes
Inclusion criteria
* Participated in the ADORE trial ( R01 HD083292)
Exclusion criteria
* History of seizures or Epilepsy * Pregnant at screening * Ineligible to complete MRI due to metal in the body
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiometabolic Biomarkers - Glucose & Lipids | Baseline | Assess differences in cardiometabolic biomarkers between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. |
| Cardiometabolic Biomarkers - Insulin | Baseline | Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control. |
| Cardiometabolic Biomarkers - Hemoglobin A1C | Baseline | Assess cardiometabolic marker values differences between the women diagnosed with a hypertensive disorder of pregnancy to the values of the healthy control. |
| Neurovascular Hemodynamics - Heart Rate | Baseline | Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Heart rate was measured using a 5-lead electrocardiogram. |
| Neurovascular Hemodynamics - Mean Arterial Pressure | Baseline | Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Mean arterial pressure was measured with each heart beat using a specialized cuff placed on the finger. |
| Neurovascular Hemodynamics - Cerebral Blood Flow | Baseline | Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Cerebral blood flow, the velocity at which blood travels through the middle cerebral artery, was measured using transcranial doppler ultrasound. |
| Neurovascular Hemodynamics - Pulse Wave Velocity | Baseline | Assess differences in heart rate, mean arterial pressure, cerebral blood flow, and pulse wave velocity between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. Pulse wave velocity is an indicator of vessel stiffness and was measured using a specialized blood pressure cuff placed on the upper thigh. |
| Brain Structure | Baseline | Assess differences in brain structure between women diagnosed with a hypertensive disorder of pregnancy and healthy controls using fMRI. A T1-weighted structural scan was completed (3D MPRAGE sequence). Structural data was segmented using FreeSurfer to quantify brain volumes. Volumes are reported in cubic millimeters (mm\^3). |
| Brain Functional Connectivity | Baseline | Assess differences in brain functional connectivity between women diagnosed with a hypertensive disorder of pregnancy and healthy controls using fMRI. A resting state scan run of gradient echo blood oxygen level dependent (BOLD) scans was completed. Resting state data was processed using analysis protocols that explored functional neural networks (i.e., default mode network (DMN), attention network, salience network). Functional connectivity is reported as Fisher z-transformed correlation coefficients derived from fMRI data. |
| Alzheimer's Disease-related Biomarkers | Baseline | Assess differences in Alzheimer's disease-related biomarkers between the women diagnosed with a hypertensive disorder of pregnancy and healthy control. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORHolly R Hull, PhD
University of Kansas Medical Center
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Continuous | 41.8 years STANDARD_DEVIATION 3.46 |
| BMI | 29.550 kg/m^2 STANDARD_DEVIATION 6.7084 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 4 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 8 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 1 Participants |
| Race (NIH/OMB) Black or African American | 1 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 1 Participants |
| Race (NIH/OMB) White | 20 Participants |
| Sex: Female, Male Female | 12 Participants |
| Sex: Female, Male Male | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 12 | 0 / 12 |
| other Total, other adverse events | 0 / 12 | 0 / 12 |
| serious Total, serious adverse events | 0 / 12 | 0 / 12 |
Outcome results
None listed