Bordetella Pertussis, Whooping Cough, Influenza, Mycoplasma Pneumoniae, RSV Infection, SARS CoV 2 Infection
Conditions
Brief summary
Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and rarely death. In the 2022-2023, influenza, RSV and SARS-CoV-2 viruses infected a large number of children which strained the pediatric healthcare system in many jurisdictions. Unfortunately, there continues to be limited data on duration of infectiousness and transmission risk of these viruses to inform public health decisions during times when there is significant circulation of these viruses.
Interventions
DIAGNOSTIC_TESTDaily Influenza, RSV or SARS-CoV-2 PCR testing for 14 days
Each participant will undergo daily PCR testing for Influenza, RSV or SARS-CoV-2 to assess viral dynamics
Sponsors
The Hospital for Sick Children
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to No maximum
Healthy volunteers
No
Inclusion criteria
Viral dynamics (primary outcome): * The child must be less than 18 years of age * Have a positive PCR sample for influenza, RSV or SARS-CoV-2, * Have any one of the symptoms listed to meet testing eligibility: fever, cough, shortness of breath, decreased or loss of taste or smell, muscle aches/joint pains (unusual, long lasting, not related to injury), extreme tiredness (unusual fatigue not otherwise explained), sore throat, runny or stuffy/congested nose, headache (new, unusual, long-lasting), nausea/vomiting and/or diarrhea, and * Be within 5 days of symptom onset Household testing inclusion criteria (secondary outcome): -Any individual in the same household (i.e. household contacts, defined as residing at the same address) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis Classroom testing inclusion criteria (secondary outcome): -Any individual in the same classroom (i.e. classroom contacts) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis (i.e. case identified through the THS program)
Exclusion criteria
Viral dynamics (primary outcome): -Participants will be ineligible if they are more than 5 days from symptom onset
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To describe the viral dynamics of influenza, RSV and SARS-CoV-2 over time among children <18 years of age. | 14 days | The correlation between symptom onset and symptom resolution and viral load for each virus will be described. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To assess the impact of various host factors on viral dynamics | 14 days | The correlation between host factors and viral dynamics will be explored. |
| To assess the frequency of influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in households. | Within 14 days of case identification | The number of household contacts that are tested and test positive for the same respiratory virus (influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, bordetella pertussis) will be described. |
| To examine the risk factors for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in households | Within 14 days of case identification | The correlation between household characteristics and transmission of each of the viruses will be explored. |
| To assess the frequency of influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in classrooms. | Within 14 days of case identification | The number of classmates in the classroom that are tested and test positive for the same respiratory virus (influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, bordetella pertussis) will be described. |
| To examine the risk factors for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae and bordetella pertussis transmission in classrooms | Within 14 days of case identification | The correlation between classroom characteristics and transmission of each virus in classrooms will be explored. |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORMichelle Science
The Hospital for Sick Children (SickKids)
Outcome results
None listed