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Initial Clinical and CBCT Outcomes of Enamel Matrix Derivative-Based Regenerative Therapy in Vertical Bone Defects

Initial Clinical and CBCT Outcomes of Enamel Matrix Derivative-Based Regenerative Therapy in Vertical Bone Defects

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06639555
Enrollment
48
Registered
2024-10-15
Start date
2022-06-24
Completion date
2023-08-15
Last updated
2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vertical Alveolar Bone Loss

Brief summary

Study of the effectiveness of the application of regenerative therapy with autogenous, platelet-rich plasma in vertical defects Investigation of the effectiveness of the application of regenerative therapy with enamel matrix derivatives in vertical bone defects Study of the effectiveness of the application of guided tissue regeneration in vertical bone defects with Barrier membrane and Barrier membrane and autogenous platelet-rich plasma

Interventions

PROCEDUREPRP( platelet rich plasma)

regenerative therapy with PRP for vertical bone defects

PROCEDUREEMD (Enamel Matrix Derivative)

regenerative therapy with EMD for vertical bone defects

PROCEDUREGuided Tissue Regeneration (barrier membrane)

guided tissue regeneration with barrier membrane alone for vertical bone defects

PROCEDUREGuided Tissue Regeneration(barrier membrane and PRP)

guided tissue regeneration with barrier membrane and PRP for vertical bone defects

Sponsors

Tsvetalina Gerova-Vatsova
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* good oral hygiene * written informed consent * age * no systemic diseases

Exclusion criteria

* smokers * horizontal bone loss * untreated periodontium disease

Design outcomes

Primary

MeasureTime frame
Probing depth in mm6 months
Level of Margo Gingivalis in mm6 months
Clinical attachment level in mm6 months
The distance from the ECJ to the base of the bone defect in mm6 months
The distance from the ECJ to the apex of the bone defect in mm6 months
The width of the bone defect in mm6 months

Countries

Bulgaria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026