Prevalence and Serotype Distribution of Streptococcus Pneumoniae in Healthy Vietnamese Children From 6 Months to 5 Years Old

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06638333

Enrollment

800

Registered

2024-10-15

Start date

2024-11-01

Completion date

2025-12-26

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Streptococcus Pneumonia

Brief summary

This observational study is designed as a cross-sectional survey of children from 6 months and 5 years old who visit the Vietnam Vaccination Center (VNVC) system in Hanoi, Danang and Ho Chi Minh City for vaccination services. After getting the informed consent form from a parent/guardian for their child(s) to participate in the study, nasopharyngeal swab sample will be taken. His/her guardian will be interviewed face-to-face with information related to epidemiological characteristics, nutritional status, child's birth history, hospitalization history, vaccination history, recent antibiotic usage, breastfeeding time, and environmental and lifestyle factors. The goal is to document the burden and risk factors of pneumococcal infections in the community of healthy Vietnamese children. The main questions it aims to answer are: * What is the prevalence of pneumococcus in healthy children? * What is the distribution of pneumococcus serotypes in the community of healthy Vietnamese children? * What are risk factors of pneumococcus infection in the community of healthy Vietnamese children?

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

6 Months to 5 Years

Healthy volunteers

Yes

Inclusion criteria

* Children between 6 months and 5 years

Exclusion criteria

* Children with chronic diseases (including immunologic diseases, neoplastic disorders, renal, cardiac, hepatic, or hematologic diseases, broncho dysplasia, Down syndrome, chronic otitis media with effusion) * Children with acute/chronic upper or lower respiratory tract infection * Children have used antibiotics within 1 week prior to entering the study

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of pneumococcal carriage in the nasopharynx in children from 6 months to 5 years old in the Vietnamese community	Day 0 after recruitment	Pneumococcal prevalence in children by age group, sex and geographical area
Serotype distribution of pneumococcal strains in Vietnamese children from 6 months to 5 years old in the community	Day 0 after recruitment	The number of carrier individuals by serotype will be determined for age group, sex and geographical area

Secondary

Measure	Time frame	Description
Risk factors associated with pneumococcal carriage	Day 0 after recruitment	Gender, age, urban vs rural setting, environmental, lifestyle factors and other factors will be analyzed.

Countries

Vietnam

Outcome results