Coronary Artery Bypass Grafting
Conditions
Keywords
Intranasal, nitroglycerin, hemodynamic response, larayngoscopy, intubation, coronary artery bypass grafting
Brief summary
Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.
Detailed description
The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.
Interventions
Received 1 mg of nitroglycerin intranasally two minutes prior to laryngoscopy and intubation
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Both genders * Patients undergoing coronary artery bypass grafting surgery. * Patients aged 35-60 years. * Ejection Fraction between 50-60%. * American Society of Anesthesiologists Classification 3-4.
Exclusion criteria
* Known hypersensitivity to nitroglycerin. * Anticipated difficult airway. * Emergency surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean aterial pressure | 5 minutes post intubation | Mean arterial pressure was measured prior to and after intubation |
| Heart rate | 5 minutes post intubation | Heart rate was measure prior to and after intubation |
| Systolic blood pressure | 5 minutes post intubation | Systolic blood pressure was measure prior to and after itubation |
| Diastolic blood pressure | 5 minutes post intubation | Diastolic blood pressure was measure prior to and after intubation |
Countries
Pakistan
Outcome results
None listed