Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation

Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation Versus Allograft Only for Subsequent Implant Placement in the Maxillary Posterior Region, a Randomized Clinical Trial

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06636461

Enrollment

Registered

2024-10-10

Start date

2024-11-01

Completion date

2025-02-01

Last updated

2024-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hopeless Tooth

Keywords

hopeless tooth lesion or affected periodontium

Brief summary

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by radiographic and Histomorphometry ) utilizing microfragmented adipose tissue loaded on allograft versus allograft only for maxillary posterior ridge preservation

Detailed description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on allograft will be utilized for the study group and allograft only for the control group. After 3-6 months, assessment of dimensional changes ( RG height & width) on CBCT is performed and Histomorphometry will be evaluated via core biopsy at the time of implant placement in both groups. Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height and width from base line (1week) to 3-6 months postoperatively.

Interventions

PROCEDUREmicrofragmented adipose tissue loaded on allograft

microfragmented adipose tissue loaded on allograft on ridge preservation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

21 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium. Age group: above 18 years • Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

Exclusion criteria

* • General contraindications to implant surgery. * Subjected to irradiation in the head and neck area less than 1 year before implantation. * Poor oral hygiene and motivation. * Severe bruxism or clenching. * Systemic, immunologic or debilitating diseases that could affect normal bone healing & local pathosis. * Treated or under treatment of intravenous amino-bisphosphonates. * Active infection or severe inflammation in the area intended for implant placement. * Patients participating in other studies, if the present protocol could not be properly followed. * Heavy somkers

Design outcomes

Primary

Measure	Time frame	Description
Alveolar ridge hight (bone quantity )	Alveolar ridge hight (bone quantity ) by CBCT after 3-6 months	By CBCT

Secondary

Measure	Time frame	Description
Alveolar ridge width.	Alveolar ridge width. by CBCT after 3-6 months	By CBCT

Countries

Egypt

Contacts

Primary Contactmaha alnahdi, BDS

maha.alnahdi@dentistry.cu.edu.eg01145684357

Backup Contacthesham elhawary, prof

hesham.elhawary@dentistry.cu.edu.eg01144446373

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026