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Clinical Evaluation of Dimethyl Sulfoxide Wet Bonding Technique

Clinical Evaluation of Dimethyl Sulfoxide Wet Bonding Technique: A Randomized Controlled Trial

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06635382
Enrollment
68
Registered
2024-10-10
Start date
2024-10-20
Completion date
2025-04-01
Last updated
2024-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dimethyl Sulfoxide

Brief summary

Dimethyl sulfoxide (DMSO) wet bonding has shown promising results in several in vitro studies. However, there are a lack of clinical trials which prove the advantages of this technique. The aim of the study is to clinically assess the effect of DMSO wet bonding on composite restoration in non carious cervical lesions.

Interventions

OTHERUniversal single bond adhesive

Will be applied and light cured for 20 seconds.

OTHERDMSO

DMSO application on tooth followed by active application of universal single bond adhesive and light cured for 20 seconds.

Sponsors

Manipal University College Malaysia
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Two similar non carious cervical lesions (NCCLs) on the facial/labial surfaces of premolars. * NCCLs of score 1-3 on the Smith and Knight tooth wear index. * Favorable occlusion and teeth are in normal contact.

Exclusion criteria

* NCCLs on the lingual surface. * Medically compromised individuals. * Periodontally compromised teeth. * Bruxism and visible wear facets in the posterior dentition. * Fractured or visibly cracked premolars and canines. * Known allergies to resin-based restorative materials. * Presently undergoing orthodontic treatment. * Abutment teeth for fixed or removable prostheses.

Design outcomes

Primary

MeasureTime frameDescription
Fracture of materialFrom treatment to 3-6 months follow upDifferent fracture patterns and retention failures may occur in relation to the type of restoration: cracks, chipping/ delamination, bulk fractures, or incomplete and complete loss of retention. Assessed by Visual examination and short air drying. Criteria set from Clinically excellent/very good(sufficient) (Score 1) to Clinically poor (entirely insufficient)(Score 5)
Marginal adaptationFrom treatment to 3-6 months follow upThere are different interfaces between the dental hard tissue, restorative material, and adhesive and/or luting resin/cement layer. Each interface can degrade and potentially alter marginal adaptation. In clinical practice, it is impossible to distinguish failures between the different interfaces. Therefore, only the marginal adaptation as such can be assessed by visual examination and short air drying. Scores given depending upon the quality of restoration from Clinically excellent/very good (sufficient) (Score 1) to Clinically poor (entirely insufficient) (Score 5)

Contacts

Primary ContactAnchu Rachel Thomas
rachel.thomas@manipal.edu.my1-700-811-662

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026