Rate of Tooth Movement in Orthodontic Patients
Conditions
Brief summary
it is a randomized control trial and aims at investigating the effects of PRF on rate of tooth movement and root length to be tested on larger sample size of pakistani population
Interventions
BIOLOGICALPlatelet rich fibrin
Only the test side that will be intervened with i-PRF will be obtained from the upper liquid layer and will be placed in dental injectors using a 27 mm gauged needle. During the first application the amount of i-PRF will be standardized as 4 mL and injected through intra-ligamental into the disto-buccal and disto-palatal side of the canine tooth (2 mL for each side) and at the time of second intervention i.e 8th week form the baseline intramucosal injection will be administered equidistant from the maxillary canine and second premolar, 2ml on buccal side and 2ml on palatal side) after anesthetizing the region with local anesthesia (2% Lignocaine).
Sponsors
Dow University of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
This trial will be a double-blind trial where the examiner and the patient both will be blind. Since the placebo and i-PRF will be in similar looking glass tubes the patient and the investigator/ examiner who is the orthodontist will not know which side of the maxilla has been intervened with i-PRF and which one with the placebo injection.
Intervention model description
All routine history and medical records will be taken before commencing the treatment. The rate of orthodontic tooth movement and the root length of the canine will be measured using the calipers on cast model and the digital periapical X-Ray respectively using millimeter unit. All measurements will be recorded at the baseline (T0) followed by at the end of 8weeks (T1), before giving second dose of PRF, to assess single dose PRF outcomes and at end of 20 weeks (T2) to assess multiple dose PRF outcomes. Periapical x-rays to assess effect of single dose of PRF on root length will be taken at baseline (T0) just before injecting PRF and starting canine retraction and will be compared with the second periapical x-ray taken at the end of 8week (T1), just before injecting second dose of PRF.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who give written consent to participate in the research * Orthodontic patients with good oral hygiene * Patients with periodontal probing depths≤3 mm with no bone loss * Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction * Patients treated with canine retraction utilizing maximum anchorage in the maxillary arch from trans-palatal arch anchorage device * Patients with mild to moderate crowding in maxillary arch * Patients with no previous history of orthodontic treatment
Exclusion criteria
* patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded. Other
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| : Distance of canine retraction in millimeters / month in different groups-control, single dose PRF and multiple doses of PRF. | 5 months |
Secondary
| Measure | Time frame |
|---|---|
| Difference in root length of canine measured before and after canine retraction and compared amongst different groups | 5 month |
Countries
Pakistan
Contacts
Primary ContactFahad Iqbal Farooqui, bds
Backup ContactHareem Sultan, Bds, Fcps, Morth
Outcome results
None listed