General Anaesthesia During Pregnancy
Conditions
Keywords
anaesthesia, anaesthesia-induced neurotoxicity, pregnancy
Brief summary
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy. While these surgeries are necessary, there is a concern that the anaesthesia might affect the baby's brain development. However, there isn't enough research to know for sure how this exposure might impact the child's intelligence or behavior later in life. The goal of this cohort study is to compare the intelligence and neurodevelopmental outcome of children prenatally exposed to general anaesthesia for maternal abdominal surgery with those of unexposed children and with those of children prenatally exposed to maternal inflammation.
Interventions
OTHERAge-appropriate Wechsler Intelligence Test
2.5-6 years: Wechsler Preschool and Primary Scale of Intelligence for children (WPPSI IV) 7-16 years: Wechsler Intelligence Scale for Children (WISC V) \>17 years: Wechsler Adult Intelligence Scale (WAIS IV)
OTHERDisruptive Behavior Disorders Rating Scale
Dutch version of the Disruptive Behavior Disorders Rating Scale
OTHERSocial Responsiveness Scale
3-18 years: social responsiveness scale 2 (SRS-2) \>19 years: Social Responsiveness Scale - Adult version (SRS-A)
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
2 Years to 27 Years
Healthy volunteers
Yes
Inclusion criteria
Prenatal anaesthesia exposure: Inclusion Criteria: * Prenatal anaesthesia exposure: Children exposed in utero to maternal general anaesthesia to allow laparoscopy or laparotomy for appendicectomy, adnexal pathology, cholecystectomy or for diagnostic procedures to rule out intra-abdominal pathology * No prenatal anaesthesia exposure: Children not exposed to general anaesthesia for non-obstetric or obstetric (e.g. cesarean section) surgery in utero * Children exposed to inflammation: Children born to mothers diagnosed with inflammatory bowel disease (IBD) who had a flare-up during pregnancy without being exposed to general anaesthesia for non-obstetric or obstetric (e.g. cesarean section) surgery in utero. * Children born in 2000-2023 * (Parental) informed consent
Exclusion criteria
* Children whose mothers underwent obstetric surgery or foetal surgery/interventions during the same pregnancy. * No Dutch-speaking children * Diagnosis of severe disability of genetic origin (e.g., Fragil X, Down syndrome,…), history of head trauma, major congenital birth defects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wechsler full-scale intelligence quotient | 1,5 hours (duration of intelligence testing and completion of questionnaires) | Primary outcome will be the Wechsler full-scale intelligence quotient which will be assessed using the Wechsler Preschool and Primary Scale of Intelligence for children with an age of 2.5-6 years, the Wechsler Intelligence Scale for Children for children with an age of 7-16 years and the Wechsler Adult Intelligence Scale for children with an age of ≥ 17 years. |
Countries
Belgium
Outcome results
None listed