Chemotherapy Effect, Hand Function, Peripheral Neuropathy
Conditions
Keywords
Breast cancer, hand dexterity, hand grip strength, task-oriented training, Taxanes-induced peripheral neuropathy
Brief summary
Chemotherapy based on taxanes is commonly used to treat breast cancer. However, chemotherapy-induced peripheral neuropathy (CIPN), a side effect of taxanes, impairs a patient's grip strength, hand dexterity, and upper extremity function which affects quality of life (QOL).
Detailed description
Task-oriented training, a type of exercise where exercises are organized into tasks, concentrates on enhancing particular functional abilities through useful, goal-directed activities. So, the purpose of the study to explore the effectiveness of task-oriented training (TOT) on grip strength, hand dexterity and upper extremity function in patients with taxanes-induced peripheral neuropathy.
Interventions
OTHERTask oriented training exercises
Task oriented training is a type of exercises in form of tasks using papers, pens, scissors, clips, coins, screws and clay
OTHERTraditional physical therapy
Traditional physical therapy inform of mobilization, strengthening exercises of hand and streching exercises.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
Single-blind, randomized, controlled trial
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients were females only. * Their ages range from 35 to 65. * All patients suffered from CIPN after using taxanes (anti-cancer agent causing neurotoxic effect). * Diagnosis of CIPN was determined based on symptom history or the presence of stocking glove pattern distal dysesthesias, pain and numbness beginning after taxanes intake. * All patients enrolled to the study had their informed consent. * Patients suffer from affected brachial plexus.
Exclusion criteria
* Patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), CNS diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy). * Patients had bone, brain or spinal cord metastases. * Patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study. * Patients exhibited only acute neuropathy like in patients using oxaliplatin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hand grip strength | At baseline and after four weeks of intervention. | Hand grip strength (HGS) was measured in the dominant hand for each patient using The CAMRY dynamometer |
| Hand dexterity | At baseline and after four weeks of intervention. | The nine-hole peg test was used to assess the hand dexterity |
| Hand function | At baseline and after four weeks of intervention. | Each patient was asked to answer the questions of the six scales in the Arabic version of Michigan hand questionnaire (1- Overall hand function, 2-Activities of Daily Living, 3- Work performance, 4- Pain, 5- Aesthetics, and 6- Satisfaction with hand function) |
Countries
Egypt
Outcome results
None listed