Immature Teeth, Necrotic Pulp
Conditions
Keywords
regenerative endodontic procedure
Brief summary
This trial aims to study the effect of photoactivated disinfection using Diod laser (810 nm) to activate photosensitive nanoparticle chitosan as an endodontic irrigant versus sodium hypochlorite followed by saline and then EDTA 17% on 1) postoperative pain and 2) the success of revascularization in patients with necrotic immature maxillary anterior teeth using a randomized clinical trial design.
Detailed description
randomized clinical trial will be conducted to investigate and compare the efficacy of photosensitized nano-chitosan 2% as an endodontic disinfectant during revascularization versus sodium hypochlorite, followed by EDTA 17% according to the standardized protocol of the American Association of endodontics. Twenty individuals with necrotic, immature permanent anterior teeth will be recruited. They will be randomly assigned into two groups according to the received intervention: control group and test group. pain will be evaluated as a primary outcome at 24 hours and one week post-intervention using numerical rating scale (NRS). In addition, the root development in terms of change in root length and apical foramen diameter and periapical bone healing will be evaluated as secondary outcomes using cone beam tomography.
Interventions
PROCEDUREregenerative endodontic procedure using blood clot according to AAE
regenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using AAE protocol
PROCEDUREregenerative endodontic procedure using photo activated nanochitosan 2%
regenerative endodontic procedure using blood clot to replace the necrotic pulp tissues in immature teeth with a pulp like to tissue to complete root development. using photosensitized nanochitosan for root canal disinfection
Sponsors
Minia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* o Immature necrotic maxillary incisor with open apex greater than 1 mm. * Teeth where pulp space are not needed for post and core. * A restorable tooth. * Patients should be free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent and will commit to follow-up period.
Exclusion criteria
* o Non-restorable teeth. * Teeth with root fractures, internal or external root resorption. * Teeth with mature fully developed root with closed apex * Patients with any systemic disease that may affect predictable outcome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain intensity assessed by numerical rating scale | 24 hours and 1 week after completion of the procedure | postoperative pain using numerical rating scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| root development | 6 months, 1 year postoperative | change of root length |
| Apical foramen closure | 6 months, 1 year postoperative | change in apical foramen diameter |
| periapical bone healing | 6 months, 1 year postoperative | change in the area of periapical lesion |
Contacts
Primary ContactMohamed Abdelmawla, assisstant lecturer
Outcome results
None listed