Knee Osteoarthritis
Conditions
Keywords
knee osteoarthritis, platelet rich plasma, ozone therapy
Brief summary
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered. In advanced-stage gonarthrosis, steroid injections may respond. However, in mild and moderate knee arthritis, regenerative methods come to the forefront because the joint cartilage is still partially/completely intact. PRP and ozone therapy are frequently applied intra-articular treatments. This study will compare the effects of both injection methods on clinical outcomes.
Detailed description
Knee osteoarthritis is a common arthrosis that can be encountered frequently with increasing life expectancy. In mild-moderate stages, hot/cold applications, drug treatments and exercise applications are usually applied, while in those who do not respond, physical therapy or intra-articular injection treatments are applied. This retrospective study aims to examine the effects of intra-articular Platelet Rich Plasma (PRP) and ozone therapy on pain, functionality and quality of life in patients with Stage 2-3 gonarthrosis according to the Kelgren-Lawrence (KL) Classification.
Interventions
OTHERPRP injection
A total of 3 doses of intra-articular PRP were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.
OTHEROzone therapy
A total of 3 doses of intra-articular ozone therapy were applied to the symptomatic knees of the patients under ultrasound guidance, once a week.
Sponsors
Sisli Hamidiye Etfal Training and Research Hospital
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 30-70 years old, Stage 2-3 gonarthrosis according to KL * Voluntariness to participate in the study
Exclusion criteria
* Cognitive dysfunction * General medical condition is not suitable for injections and evaluations * History of knee injections in the last 3 months * History of previous knee surgery * Bleeding disorders or those taking medications that may cause bleeding disorders after injections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain-Numerical Rating Scale | From enrollment to the end of treatment at 3rd month | Pain level will be evaluated with the Numerical Rating Scale. (minimum: 0, maximum: 10) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain, stiffness and physical function-WOMAC | From enrollment to the end of treatment at 3rd month | The Western Ontario and McMaster Universities Arthritis Index (WOMAC) is a widely used self-administered health status measure used in assessing pain, stiffness, and function in patients with OA of the hip or knee. The test questions are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each sub-scale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. Usually a sum of the scores for all three sub-scales gives a total WOMAC score. |
| Quality of life-SF-12 | From enrollment to the end of treatment at 3rd month | The 12-item short-form health survey (SF-12) quality of life scale was used to evaluate general quality of life. It was presented as a physical component score (PCS) and mental component score (MCS). Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning. |
Countries
Turkey (Türkiye)
Outcome results
None listed