Renal Arterial Resistive Index as a Noninvasive Biomarker of Disease Activity in Lupus Nephritis Patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06631404

Enrollment

Registered

2024-10-08

Start date

2024-10-01

Completion date

2025-10-30

Last updated

2024-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lupus Nephritis

Brief summary

Systemic Lupus Erthymatosous (SLE) is achronic inflammatory multi system auto immue disease characterized by pathogenic auto anti bodies production against nuclear structures (Bolouri et al.,2022), SLE affecting mainly woemn of childbearing age and is chracterized by unpredictable flares and remissions , disease variety varied from mild episode disorder to arpidly progressive life -threatening illness.. LN is diagnosed by either the presence of proteinuria \>0.5g/day. active urinary sediment , or an unexplained rise in serum creatinine there fore , identifying new invasive biomarkers of LN severity and outcome is mandatory, Renal Arterial resistive index ( RRI) is anon invasive biomarker that has been studied as apotential indicator of disease activity in LN patients.

Interventions

DIAGNOSTIC_TESTrenal doppler

doppler srudy on renal arteries bilaterally , and detection of RI of renal artery

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Inclusion criteria

* Aged ≥18 years. * SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) classification criteria and matched controls. * Patients cooperative and can answer questions. * Patients who are able and willing to give written informed consent.

Exclusion criteria

* • Individuals with other autoimmune diseases. * Diabetes. * Hypertension. * Heart failure. * Hepatic diseases. * Chronic renal failure. * Renal artery stenosis. * Renal vein thrombosis. * Intrarenal arteriovenous fistula. * Obstructive nephropathy. * Urinary tract obstruction that could affect RI of intra renal arteries. * Un cooperative patients. * Patients not able and willing to give written informed consent.

Design outcomes

Primary

Measure	Time frame	Description
doppler for renal artery	1 year	resistive index of renal artery

Countries

Egypt

Contacts

Primary ContactDoaa R Abdelkarim, resident

doaa_rabea_post@med.sohag.edu.eg01027673294

Backup ContactEsam M Abualfadl, professor

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026