Prehypertension (elevated Blood Pressure) or Hypertension
Conditions
Brief summary
It was hypothesized that aerobic exercise with blood flow restriction (BFR) induced post exercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors. Ten male participants participated in this study. The participants were randomly assigned to walk for 10 minutes at 6.4 k/m, 0% grade with or without BFR after taking histamine receptor blockade. Following exercise, BP was measured at 10 min interval for 60 minutes. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), and total peripheral resistance (TPR) were evaluated.
Interventions
GENETICH1 receptor blockade: 540 mg (Allegra), H2 receptor blockade: 40 mg (Pepcid AC)
Subjects ingested fexofenadine (540 mg, tablet) at least 50 minutes before and famotidine (40 mg, tablet) 1 hour 50 minutes before the onset of each protocol because these dose of oral fexofenadine and famotidine reaches its peak concentration at around 1 h and 2 h, respectively
Sponsors
California Baptist University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* good health, * nonsmokers * those not taking medications that could affect cardiovascular function
Exclusion criteria
* hypertension * muscular skeletal disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-exercise hypotension before and after the histamine blockade | 10 min, 20 min, 30 min, 40 min, 50 min, and 60 min post exercise | Blood pressure change during 60 min (10 min interval) after BFR exercise |
Countries
United States
Outcome results
None listed