Autotransfusion Device, Platelets
Conditions
Keywords
Cardiac surgery, Autotransfusion device, Platelets
Brief summary
Cardiac surgery is a bleeding-risk surgery and frequently requires blood transfusion. Intraoperative autotransfusion devices are used to aspirate, process and retransfuse patients' blood. These devices are effective in recovering red blood cells and limiting the need for transfusion of packed red blood cells. Some devices, such as I-SEP's SAME®, can also be used to recover platelets, but their effectiveness has not yet been evaluated in real-life situations. The aim of this study is therefore to investigate the evolution of platelet counts following the use of an intraoperative recovery device in adult patients undergoing standard cardiac surgery
Interventions
DEVICEAutotransfusion device
Standard cardiac surgery using I-SEP and SAME™ autotransfusion device
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients over 18 years of age * Having undergone standard cardiac surgery (excluding redux surgery, dissection, endocarditis, circulatory assist and transplants) * Treated with an autotransfusion device during the surgery * Subject having expressed their consent to the study
Exclusion criteria
* Anemia less than 7 g/dL * Pregnant women * Redux surgery, dissection, endocarditis, circulatory assistance, and transplants * Contraindication to the use of an autotransfusion device * Impossibility of giving the subject informed information
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet count | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device | Study the evolution of platelet counts following the use of I-SEP's SAME™ autotransfusion device in major patients undergoing standard cardiac surgery |
Secondary
| Measure | Time frame |
|---|---|
| To study the evolution of platelet function (flow cytometry and flow aggregation) following the use of a autotransfusion device in major patients undergoing standard cardiac surgery. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| Study the evolution of platelet function according to the autotransfusion device used. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| Study post-operative bleeding volume as a function of autotransfusion device type. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| To study the evolution of platelet count following the use of the autotransfusion device (other than SAME) in major patients undergoing standard cardiac surgery. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| Study the intensity of post-operative inflammatory syndrome as a function of the autotransfusion device used. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| Study platelet adhesion to the autotransfusion device membranes using electron microscopy. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
| Study the volume of labile blood product transfusion according to the autotransfusion device used. | Before the use of blood sparing system and 5 minutes after the end of the infusion of blood from the autotransfusion device |
Countries
France
Contacts
Primary ContactCharles TACQUARD, PHU
Outcome results
None listed