Intensive Care Patients, Osteoarticular Infection, Prosthetic Joint Infection
Conditions
Keywords
Osteoarticular sepsis, sepsis, osteoarticular prothetis, intensive care, critical care, prosthetic joint infection
Brief summary
This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses). The main objective of the study is to describe the profile, care trajectories during the stay (before or after surgery) and prognosis of patients admitted to critical care with such an infection. We also aim to compare prognosis between different groups of patients sharing the same profile and care trajectory, and to assess independent risk factors associated with 2-year mortality among the study population. Finally, we will describe the microbiological and resistance profile of severe osteoarticular device infections requiring critical care admission in France. This is a descriptive and analytical observational study open to all French public and private hospitals. Patient data will be retrieved prospectively from patient source files. Only 2-year data (vital status, functional data) will be collected specifically for the study, by telephone contact with the patient or his or her support person.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient at least 18 years old. * Hospitalization in critical care (intensive care unit or continuing care unit) between 2018 and 2022 of at least 48 hours, with prosthetic joint infection (hip, knee or shoulder prosthesis infection) as the main or associated diagnosis.
Exclusion criteria
* Infection on osteosynthesis material * Infection on spinal equipment * Patient with several infected prostheses * Recurrence of infection on prosthesis with the same microorganism * Patient opposing data collection * Patient under legal protection. * Pregnant or breast-feeding patient. * Patient deprived of liberty.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The profile, trajectories of care during the stay (before or after surgery) and the prognosis of patients admitted to intensive care for joint prosthesis infection over a 2-year period after admission to intensive care. | 2 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Composite endpoint reflecting poor clinical outcome | 2 years | * Mortality, measured in critical care, at 30 days, 1 year and 2 years * Therapeutic failure at 2 years, defined as mechanical or septic failure. * Functional failure at 2 years, defined as failure to resume walking and usual activities, to return home, or to regain autonomy. |
| Mortality at 2 years | 2 years | — |
| Description of pathogens found in intraoperative samples, and their resistance spectrum | 2 years | — |
Countries
France
Contacts
STUDY_DIRECTORCarine PARE
Assistance Publique - Hôpitaux de Paris
Outcome results
None listed