Non-Small Cell Lung Cancer
Conditions
Keywords
Video-Assisted Thoracoscopic Surgery, Robot-Assisted Thoracoscopic Surgery, open approach
Brief summary
The study is a retrospective observational study. The study is designed to be multicentric and international and it will analyze medical records from selected patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy. There are no risks for the patients, as this is a retrospective data collection.
Detailed description
The use of neoadjuvant chemo-immunotherapy for the treatment of non-small cell lung cancer (NSCLC) is increasing. However, there is limited research comparing the feasibility and oncologic efficacy of robot-assisted thoracoscopic surgery (RATS), video-assisted thoracoscopic surgery (VATS), and open lung resection, in patients already treated with neoadjuvant chemo-immunotherapy. This study aims to evaluate the benefits of RATS compared to VATS and open surgery in terms of short-term outcomes for patients with NSCLC undergoing neoadjuvant chemo-immunotherapy. All adult patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection from 01-01-2016 to 31-03-2024 by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy will be included. Patients are divided into three groups: robotic lung resection; video-assisted thoracoscopic (VATS) lung resection; open lung resection.
Interventions
None listed
Sponsors
Memorial Sloan Kettering Cancer Center
Istituto Clinico Humanitas
Regina Elena Cancer Institute
Baptist Health South Florida
West Virginia University
Scientific Institute San Raffaele
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of clinical or pathological stage IIB (T1-2, hilar N1, M0) and III (any T, N1-2, M0) NSCLC surgically treated with robotic, VATS and open approach with radical intent from 1st of January 2016 to 31st of March 2024 * Received neoadjuvant chemo-immunotherapy or immunotherapy alone * Age \>= 18 years old at the moment of surgery
Exclusion criteria
* Age \<18 years old at the moment of surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach | 30-90 days after surgery | The investigators will measure the perioperative complications of VATS approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale. |
| The perioperative complications of robotic approach | from the surgery at 30-90 days after | The investigators will measure the perioperative complications of robotic lung resection in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale. |
| The perioperative complications of the open approach | 30-90 days after surgery | The investigators will measure the perioperative complications of open approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radicality of the resection | from 30 days after surgery | Radicality of the resection in the approaches |
| Duration of surgery | from 30 days after surgery | Duration of the surgery based on the approach measured in minutes |
| Survival analysis | from 3 to 5 years after surgery | Presence or absence of local and distant relapse |
| Oncological treatment | from 30 days after surgery | Response of the patient to oncological treatment |
| Quality of lymphadenectomy | from 30 days after surgery | Number of lymphonodes station resected |
| Conversion rate | from 30 days after surgery | Number of surgery procedures converted |
Countries
Italy, United States
Contacts
Primary ContactPierluigi Novellis, Medical Doctor
Outcome results
None listed