Obesity
Conditions
Keywords
Obesity, Bariatric surgery, Biological aging, Adipocyte dysfunction, Biological rhythms
Brief summary
While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate : 1. Whether bariatric surgery is associated with changes in biological age 2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms 3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age. To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions
Detailed description
The study of the Nantes Bariatric Surgery Cohort (NBC) aims to evaluate the impact of bariatric surgery on biological age, adipocyte dysfunction, microbiota, and biological rhythms in individuals with obesity. This observational study will include 300 participants over 3.5 years. It involves pre-operative, peri-operative, and post-operative visits to collect clinical, biological, and lifestyle data. Key assessments include anthropometrics, blood tests, questionnaires, and biocollections
Interventions
OTHERNantes bariatric surgery cohort
The participants will be individuals living with obesity undergoing bariatric surgery
Sponsors
Nantes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
: Individuals selected for bariatric surgery (starting the BC pathway within the Nantes University Hospital bariatric unit). Inclusion criteria are those of the Bariatric Surgery program. * male or female, adult over 18 years of age * BMI ≥ 35 kg/m2 with complication(s) or ≥ 40 kg/m2 with or without complication (the list of eligible complications is referenced in HAS 2024 recommendations). In the event of a change in access to bariatric surgery, this threshold could be revised without any substantial change to the protocol. * having consented to their participation in the cohort * participant affiliated to or benefiting from a social security scheme
Exclusion criteria
: * Persons protected by law (guardianship or trusteeship) or deprived of their freedom, * Pregnant women (contraindication to CB) or nursing mothers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery | 1 year | Biological age will be estimated by measuring phenotypic age. The phenotypic age will be determined from the following variable: albumin, creatinine, fasting glucose, CRP, lymphocyte count, red cell size, alkaline phosphates, leukocyte count. |
Countries
France
Contacts
CONTACTDavid JACOBI, PU-PH
PRINCIPAL_INVESTIGATORDavid JACOBI, PU-PH
Nantes University Hospital
Outcome results
None listed