Laparoscopic Abdominal Surgery, Mechanical Power, Mechanical Ventilation, Optimum PEEP
Conditions
Keywords
Mechanical Power, Optimum PEEP, Laparoscopic abdominal surgery, mechanical Ventilation
Brief summary
The aim of this study is to compare the effects of standard and optimum positive end expiratory pressures on mechanical power during laparoscopic surgeries.
Detailed description
Perioperative pulmonary complications and ventilator-associated lung injury are challenging issues for anesthesiologists, especially after laparoscopic surgeries. An increasing number of studies suggest lung protective ventilation (LPV) strategies in these patients. It is recommended that patients&; driving pressure be kept low during LPV and positive expiratory pressure (PEEP) be applied to keep the lungs open. However, high PEEP values cannot be adequately applied in laparoscopic surgeries to reduce the restrictive peak pressure for LPV. In laparoscopic surgeries, the patients position and increased intra-abdominal pressure create pressure on the lungs. However, when the applied positive pressure ventilation is insufficient in patients, it can cause atelectasis, and when it is excessive, it can cause barotrauma or volutrauma. The threshold values determined for all these possible complications during LPV should be evaluated together. Gattinoni and colleagues (2016) explained the effect of mechanical ventilation on the lungs through a work/time formula and formulated the energy used during this work. The applied energy is spent on opening the lungs and ventilation, while the excess is consumed due to heat and resistance in the respiratory tract. The unit of this energy can be formulated in a simplified way as joule/second. The mechanical power formula makes it easier to follow by providing a single parameter instead of different threshold values for barotrauma, volutrauma and atelectrauma for the lungs. Studies have shown that applying energy over 12.6 joules is associated with lung damage. On the other hand, the relationship between the optimum mechanical power (MP) value during ventilation and low and high PEEP is not yet fully known. In laparoscopic surgeries, high PEEP application may help keep the lungs open and increase ventilation, but it may cause higher mechanical power application. In this case, the effect of high PEEP application on ventilation and patient outcomes is unclear. In this study, PEEP values and mechanical power values applied during ventilation in patients who will be operated under laparoscopic surgery will be monitored observationally and the PEEP/MP relationship will be examined in terms of patient oxygenation.
Interventions
OTHERMechanical Ventilation (MV) with Low PEEP
Mechanical Ventilation (MV) with Low PEEP During volume controlled ventilation, blood gas values and mechanical power calculations of patients ventilated at 6-8ml/kg tidal volume and 5cmH2o PEEP, I/E: 1/2, 10-14 frequency ranges will be recorded.
OTHERMechanical Ventilation (MV) with Optimum PEEP
Mechanical Ventilation (MV) with Low PEEP During volume controlled ventilation, blood gas values and mechanical power calculations of patients ventilated at 6-8ml/kg tidal volume and optimum PEEP, I/E: 1/2, 10-14 frequency ranges will be recorded. The optimum PEEP will be adjusted by titrating to the highest compliance with the open lung strategy.
Sponsors
Kocaeli City Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* within the appropriate age range * agreeing to participate in the study * again receiving lancetesthesia * volume controlled ventilation * no known lung disease * no known coronary artery disease * ASA class 1-2 patients
Exclusion criteria
* . Patients who do not want to be included in the study will not be included * Patients with intraoperative deep hypotension (mean arterial pressure <50) will be excluded. * Those who develop intraoperative hypothermia or have other anesthesia complications will be excluded. * Patients who will not be extubated postoperatively will be excluded from the study. * Those with neurological diseases or those using psychiatric medications will also be excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical power value in optimum PEEP | During the intraoperative period laparoscopic surgery | The primary aim of this study is to calculate the mechanical power values (in Joule/min) applied during ventilation among the optimum positive expiratory pressure values in patients undergoing laparoscopic surgery are higher than in patients applied low PEEP. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of high mechanical power on oxygenation in blood gases | During the intraoperative period laparoscopic surgery | The effect of high mechanical power on oxygenation (Po2 in arterial blood gas analysis) in blood gases; to compare the calculated mechanical power values and partial oxygen pressures in perioperative blood gases between the groups. |
Countries
Turkey (Türkiye)
Outcome results
None listed