Small-intestine Neuroendocrine Tumors
Conditions
Keywords
Small-intestine neuroendocrine tumor, microbiota, tumorigenesis
Brief summary
The aim of the study is to investigate the impact of the microenvironment on tumorigenesis of small intestinal neuroendocrine tumors often located in the terminal ileum, without identified driver mutations.
Interventions
OTHERBlood and stool sampling
Blood and stool sampling
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with one or more small-intestine neuroendocrine tumor with indication of surgery * Patient with consent for the collection, storage and reuse of data associated with his/her disease * Age ≥ 18 years at the time of inclusion * Non-objection statement obtained for participation in the study
Exclusion criteria
* Patients with poorly differentiated neuroendocrine carcinoma or NET (neuroendocrine tumors) of non-intestinal origin or mixed tumors (MiNEN) * Pregnant, parturient or breast-feeding women * Minors * Persons deprived of liberty by judicial or administrative decision * Adults under legal protection (guardianship, curatorship)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composition of microbiota | At day 1 and month 3 | Determination of the composition of blood, fecal, intra- and peri-tumoral microbiota in patients undergoing surgery for small-intestine neuroendocrine tumor. |
Countries
France
Contacts
Primary ContactThomas WALTER, MD, PhD
Outcome results
None listed