Post Operative Pain
Conditions
Keywords
Tap block, Dexmedetomidine
Brief summary
The aim of this study to determine the optimal dose of dexmedetomidine as an adjuvant to bupivacaine in U.S guided TAP block for preemptive analgesia In patients undergoing lower abdominal cancer surgeries.
Detailed description
The transversus abdominis plane (TAP) involves innervations of the anterolateral abdominal wall derived from T6-L1. The block can be given either by anatomical landmark technique or by using an ultrasound probe. The local anesthetic is deposited in a plane between internal oblique and transversus abdominis muscle. It provides adequate postoperative analgesia following various abdominal surgeries.Dexmedetomidine is an alpha-2 agonist that has been approved as a venous sedative and an adjuvant for pain relief .In previous studies, the addition of dexmedetomidine to bupivacaine in the TAP block has prolonged the effect of this block . So far, the optimal dose of dexmedetomidine for the TAP block has not been determined.
Interventions
DRUGDexmedetomidine as adjuvent to bupvacaine in tap block
The analgesic effect of Two different doses of dexmedetomidine as adjuvent to bupivacaine in tap block
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients will receive pre-emptive ultrasound-guided tap block with two different doses of dexmedetomidine in 20 ml volume added to 20 mL of 0.25% bupivacaine (40 ml in total) 20 ml will be applied on each side of the abdominal wall after induction of GA.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age from 18 to 65 years old * lower abdominal cancer surgery
Exclusion criteria
* patient refusal * the local anesthetic allergy * coagulopathy * local infection at the procedure site * psychic patients * patient on chronic opioid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total morphine consumption during the first 24 hours postoperatively | First 24 hours postoperative | Morphine consumption during the First 24 hours postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Severity of pain using Visual analogue scale | First 24 hours postoperative | The severity of pain at rest and on coughing will be assesd using a 10-cm vas(0 means no pain ,10 means worst pain) |
| Patient level of sedation using four point modified ramsy scale | First 24 hours postoperative | using a 4-point scale (0 = awake and alert, 1 = minimally sedated, responds to speech, 2 = moderately sedated, arousable by tactile stimulation, and 3 = deeply sedated, arousable only by painful stimulation) |
Countries
Egypt
Contacts
Primary ContactKerolos S Tawfeek, Resident
Backup ContactMohanad A Mohamed
Outcome results
None listed