Breathing Mechanics, Pulmonary Disease, Respiratory Effort, Respiratory Failure
Conditions
Brief summary
Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.
Interventions
OTHERlung mechanics, respiratory drive and effort
Patient lung mechanics and respiratory drive and effort will be measured
Sponsors
University of California, San Diego
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admitted to ICU with acute respiratory failure * On adaptive pressure control mode of ventilation * Tidal volumes set between 5-8 cc/kg ideal body weight
Exclusion criteria
* Current use of neuromuscular blockade * Inability to obtain consent from patient or surrogate decision maker * Treating clinician refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Excess tidal volume | From enrollment to end of monitoring at 4 hours | Exhaled tidal volume greater than 2cc/kg ideal body weight above intended or set tidal volume |
Countries
United States
Outcome results
None listed