Prostasin Levels in Preeclamptic Women

Prostasin Levels in Preeclampsia: A Comparative Study With Healthy Pregnancies

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06623942

Enrollment

Registered

2024-10-02

Start date

2023-01-01

Completion date

2024-03-01

Last updated

2024-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-Eclampsia

Brief summary

This study will aim to compare maternal serum prostasin levels between women diagnosed with preeclampsia and healthy normotensive pregnant controls. Participants will be divided into two main groups: those with preeclampsia and those with uncomplicated pregnancies. The preeclampsia group will further be subdivided based on the severity of the condition. Maternal serum samples will be collected from all participants, and prostasin levels will be measured using ELISA. Statistical analyses will be performed to evaluate whether prostasin levels are significantly elevated in the preeclampsia group, particularly in those with severe features, and to assess its potential as a biomarker for the condition.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of Preeclampsia: Defined by new-onset hypertension (systolic Blood Pressure ≥140 mmHg and/or diastolic Blood Pressure ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria. * Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications.

Exclusion criteria

* Multiple Pregnancies * Pregestational Diabetes * Chronic Hypertension * Systemic Diseases (Chronic kidney disease, autoimmune diseases) * Fetal Anomalies * Premature Rupture of Membranes.

Design outcomes

Primary

Measure	Time frame	Description
Maternal Serum Prostasin Levels	Up to 8 weeks (Patients will be followed from inclusion in the study until the end of their pregnancy.	To compare Prostasin Levels between the pre-eclampsia and the control group.

Countries

Turkey (Türkiye)

Outcome results