Evaluation of Biopcy Proven Glomerulonephritis Patients by Renal Shear Wave Elastography
Conditions
Keywords
elastography
Brief summary
All participants will clinically evaluated by history taking, full physical examination including body weight and assessment of fluid status, and blood and urine samples for lab analysis (serum creatinine, urea, sodium, potassium, corrected calcium, phosphorous, estimated glomerular filtration rate(GFR) by Cokcroft equation ((140 - age ) x body weight by Kg/creatinine by µmol )complete urine analysis including microscopic examination of urine , 24 hours urinary protein , haemoglobin level . All participants will undergo renal shear wave elastography measurements. Values will be obtained from the upper, middle, and lower zones of each kidney. A total of six shear wave elastography measurements will be collected to get mean elastography values (MEVs) of each participant.
Detailed description
We will collect results of MEV plus blood and urine samples of each participant then data will undergo statistical analysis to compare between MEV of healthy persons and biopcy proven glomerulonephritis patients
Interventions
DIAGNOSTIC_TESTrenal shear wave elastography
Renal shear wave elastography is a non-invasive ultrasound elastography technique that allows measurements of tissue stiffness. It provides real-time measurements of shear wave velocity (SWV) generated with an acoustic impulse, thereby providing quantitative information about tissue elasticity. Harder tissues have been shown to have higher SWV . Renal shear wave elastography will be done to both groups
Sponsors
Assiut University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
a-inclusion criteria : * adult patients aged 18 years old or more * patients diagnosed as glomerulonephritis ( biopcy proven ) and not started specific tratement in Assiut University Hospitals b.
Exclusion criteria
* patient with urinary tract obstruction * patient who has GN and started corticosteroid and/or immunosuppressive drugs * patient who has congenital anomalies in renal system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| comparisons between the shear wave elastography measurements in GN patients and healthy persons . | One year |
Countries
Egypt
Outcome results
None listed