Thyroid Cancer
Conditions
Brief summary
The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.
Detailed description
Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.
Interventions
DIETARY_SUPPLEMENTIodine excess
Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L
DIETARY_SUPPLEMENTIodine suitable
Iodine suitable areas：water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.
Sponsors
Shandong Provincial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Age range: 18\ 65 years old, gender not limited; 2. Living in the selected region for at least 5 years; 3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer; 4. The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.
Exclusion criteria
1. Diagnosed as other types of cancer or thyroid metastatic cancer; 2. There are serious comorbidities such as heart, liver, and kidney diseases present; 3. Unable to follow up on prognostic information.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with recurrence | from enrollment to the final follow-up at 5 years | Recurrence: diagnosed as the same type of thyroid cancer again by pathology |
| Number of participants with distant metastasis | from enrollment to the final follow-up at 5 years | Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland |
| All-cause mortality | from enrollment to the final follow-up at 5 years | The ratio of the total number of deaths caused by various reasons during the research period to the number of participants |
Countries
China
Contacts
Primary ContactQingling Guo
Outcome results
None listed